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Furthermore, we demonstrate that FAS mRNA expression is physiologically regulated by fasting and refeeding in the VMN but not in other hypothalamic nuclei. Thus, the VMN appears to be the hypothalamic site where regulation of FAS and feeding converge. Supporting the potential clinical relevance of these observations, reanalysis of a primary breast cancer prevention study showed that obese women treated with TMX gained significantly less body weight over a 6-year period than obese women given placebo. The finding that TMX can modulate appetite through alterations in FAS expression and malonyl-CoA levels suggests a link between hypothalamic sex steroid receptors, fatty acid metabolism, and feeding behavior.<\/jats:p>","DOI":"10.2337\/db05-1356","type":"journal-article","created":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T22:48:46Z","timestamp":1147301326000},"page":"1327-1336","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":128,"title":["Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA"],"prefix":"10.2337","volume":"55","author":[{"given":"Miguel","family":"Lo\u0301pez","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Lelliott","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulay","family":"Tovar","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kimber","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosali\u0301a","family":"Gallego","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Virtue","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Blount","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Va\u0301zquez","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Finer","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor J.","family":"Powles","sequence":"additional","affiliation":[{"name":"Parkside Oncology Clinic, London, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"O\u2019Rahilly","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asish K.","family":"Saha","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit, EBRC-827, Boston Medical Centre, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Die\u0301guez","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Vidal-Puig","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207513879500_R1","unstructured":"Wirshing DA: Schizophrenia and obesity: impact of antipsychotic medications. 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