{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:28:31Z","timestamp":1773286111636,"version":"3.50.1"},"reference-count":37,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:p>Soon after the onset of type 1 diabetes, renal hypertrophy and hyperfiltration become manifest, particularly among patients who will subsequently develop diabetic nephropathy. Whether these early renal dysfunctions are involved in the pathogenesis of diabetic nephropathy is currently unclear. We evaluated, during the same day, kidney volume and glomerular filtration rate (GFR) in 146 patients with type 1 diabetes and normal renal function. All the individuals were then monitored for a mean of 9.5 \u00b1 4.4 years for the development of microalbuminuria. Kidney volume and GFR were reevaluated in a subset of 68 patients 4 years after baseline. During follow-up, microalbuminuria developed in 27 of 146 diabetic patients. At baseline, kidney volume (312.8 \u00b1 52.6 vs. 281.4 \u00b1 46.1 vs. 236.8 \u00b1 41.6 ml\/1.73 m2, P &amp;lt; 0.05) but not GFR was increased in patients predisposed to microalbuminuria. Risk of progression was higher in patients with increased kidney volume (P = 0.0058). Patients predisposed to microalbuminuria showed a stable increase in kidney volume (P = 0.003), along with a faster decline of GFR (P = 0.01). Persistent renal hypertrophy and faster decline of GFR precede the development of microalbuminuria in type 1 diabetes. These findings support the hypothesis that renal hypertrophy precedes hyperfiltration during the development of diabetic nephropathy.<\/jats:p>","DOI":"10.2337\/db06-0592","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T21:48:55Z","timestamp":1156542535000},"page":"2620-2625","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":83,"title":["Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes"],"prefix":"10.2337","volume":"55","author":[{"given":"Gianpaolo","family":"Zerbini","sequence":"first","affiliation":[{"name":"Renal Pathophysiology Unit, Section Nutrition-Metabolism, Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Pediatrics, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Meschi","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Pediatrics, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Bognetti","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Pediatrics, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Paesano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Gianolli","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Querques","sequence":"additional","affiliation":[{"name":"Renal Pathophysiology Unit, Section Nutrition-Metabolism, Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Maestroni","sequence":"additional","affiliation":[{"name":"Renal Pathophysiology Unit, Section Nutrition-Metabolism, Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giliola","family":"Calori","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Del Maschio","sequence":"additional","affiliation":[{"name":"Universita\u0301 Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruccio","family":"Fazio","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Luzi","sequence":"additional","affiliation":[{"name":"Renal Pathophysiology Unit, Section Nutrition-Metabolism, Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Chiumello","sequence":"additional","affiliation":[{"name":"Universita\u0301 Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031208052073200_R1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association: Nephropathy in diabetes (Position statement). 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