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Primary cilia of hitherto unknown function present on these cells consequently are reduced in number and severely stunted in Rfx3\u2212\/\u2212 mice. This ciliary abnormality is associated with a developmental defect leading to a uniquely altered cellular composition of the islets of Langerhans. Just before birth, Rfx3\u2212\/\u2212 islets contain considerably less insulin-, glucagon-, and ghrelin-producing cells, whereas pancreatic polypeptide\u2013positive cells are markedly increased in number. In adult mice, the defect leads to small and disorganized islets, reduced insulin production, and impaired glucose tolerance. These findings suggest that RFX3 participates in the mechanisms that govern pancreatic endocrine cell differentiation and that the presence of primary cilia on islet cells may play a key role in this process.<\/jats:p>","DOI":"10.2337\/db06-1187","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T17:19:11Z","timestamp":1175188751000},"page":"950-959","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":97,"title":["Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas"],"prefix":"10.2337","volume":"56","author":[{"given":"Aouatef","family":"Ait-Lounis","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Baas","sequence":"additional","affiliation":[{"name":"Centre de Ge\u0301ne\u0301tique Mole\u0301culaire et Cellulaire, Universite\u0301 Claude Bernard, Villeurbanne, France"},{"name":"Equipe Diffe\u0301renciation Neuromusculaire, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanue\u0300le","family":"Barras","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Benadiba","sequence":"additional","affiliation":[{"name":"Centre de Ge\u0301ne\u0301tique Mole\u0301culaire et Cellulaire, Universite\u0301 Claude Bernard, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Charollais","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nlend Nlend","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Lie\u0300geois","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Meda","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u0301ne\u0301dicte","family":"Durand","sequence":"additional","affiliation":[{"name":"Centre de Ge\u0301ne\u0301tique Mole\u0301culaire et Cellulaire, Universite\u0301 Claude Bernard, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Reith","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207541520800_R1","doi-asserted-by":"crossref","unstructured":"Emery P, Durand B, Mach B, Reith W: RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. 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