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VFD rearing does, however, cause a range of neurobiological abnormalities, including dysregulation of the HPA axis, manifested in abnormal cerebrospinal fluid cortisol and corticotropin-releasing factor levels. We previously reported spontaneous occurrence of metabolic syndrome in 14% of normally reared peripubertal bonnet macaques given ad libitum access to standard monkey chow. Here, we show that compared with normally reared monkeys, peripubertal VFD juveniles exhibit greater weight, BMI, abdominal circumference, and glucagon-like peptide-1 and decreased glucose disposal rates during hyperinsulinemic-euglycemic clamps. Our data suggest that early-life stress during a critical period of neuro development can result in the peripubertal emergence of obesity and insulin resistance.<\/jats:p>","DOI":"10.2337\/db06-1409","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T12:48:34Z","timestamp":1177937314000},"page":"1382-1386","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":121,"title":["Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques"],"prefix":"10.2337","volume":"56","author":[{"given":"Daniel","family":"Kaufman","sequence":"first","affiliation":[{"name":"Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Banerji","sequence":"additional","affiliation":[{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Shorman","sequence":"additional","affiliation":[{"name":"Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Coplan","sequence":"additional","affiliation":[{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard A.","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Kral","sequence":"additional","affiliation":[{"name":"Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York"},{"name":"Primate Behavior Laboratory, State University of New York Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031210493835000_R1","doi-asserted-by":"crossref","unstructured":"Van Itallie TB: Stress: a risk factor for serious illness. 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