{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:38:43Z","timestamp":1783528723108,"version":"3.55.0"},"reference-count":49,"publisher":"American Diabetes Association","issue":"2","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:p>OBJECTIVE\u2014The present study investigated the relationships between reactive oxygen species (ROS), interstitial fibrosis, and renal proximal tubular cell (RPTC) apoptosis in type 2 diabetic db\/db mice and in db\/db transgenic (Tg) mice overexpressing rat catalase (rCAT) in their RPTCs (db\/db rCAT-Tg).<\/jats:p>\n                  <jats:p>RESEARCH DESIGN AND METHODS\u2014Blood pressure, blood glucose, and albuminuria were monitored for up to 5 months. Kidneys were processed for histology and apoptosis studies (terminal transferase-mediated dUTP nick-end labeling or immunostaining for active caspase-3 and Bax). Real-time quantitative PCR assays were used to quantify angiotensinogen (ANG), p53, and Bax mRNA levels.<\/jats:p>\n                  <jats:p>RESULTS\u2014db\/db mice developed obesity, hyperglycemia, hypertension, and albuminuria. In contrast, db\/db rCAT-Tg mice became obese and hyperglycemic but had normal blood pressure and attenuated albuminuria compared with db\/db mice. Kidneys from db\/db mice displayed progressive glomerular hypertrophy, glomerulosclerosis, interstitial fibrosis, and tubular apoptosis and increased expression of collagen type IV, Bax, and active caspase-3, as well as increased ROS production. These changes, except glomerular hypertrophy, were markedly attenuated in kidneys of db\/db rCAT-Tg mice. Furthermore, ANG, p53, and Bax mRNA expression was increased in renal proximal tubules of db\/db mice but not of db\/db rCAT-Tg mice.<\/jats:p>\n                  <jats:p>CONCLUSIONS\u2014Our results indicate a crucial role for intra-renal ROS in the progression of hypertension, albuminuria, interstitial fibrosis, and tubular apoptosis in type 2 diabetes and demonstrate the beneficial effects of suppressing ROS formation.<\/jats:p>","DOI":"10.2337\/db07-0013","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T20:54:28Z","timestamp":1193864068000},"page":"451-459","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":146,"title":["Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db\/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells"],"prefix":"10.2337","volume":"57","author":[{"given":"Marie-Luise","family":"Brezniceanu","sequence":"first","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chang","family":"Wei","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Che\u0301nier","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Godin","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos G.","family":"Filep","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Maisonneuve-Rosemont Hospital, Research Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Ingelfinger","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.D.","family":"Chan","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Montre\u0301al, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM) Ho\u0302tel-Dieu, Research Centre, Pavillon Masson, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207595339200_R1","unstructured":"United States Renal Data System: USRDS Annual Data Report. 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