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These data indicated that glucopenia induces transmembrane Ca2+ influx and transmitter secretion. In patch-clamped glomus cells, exposure to low glucose resulted in inhibition of macroscopic outward K+ currents and in the generation of a depolarizing receptor potential (DRP). The DRP was abolished upon removal of extracellular Na+. The membrane-permeable 1-oleoyl-2-acetyl-sn-glycerol induced inward currents of similar characteristics as the current triggered by glucose deficiency. The functional and pharmacological analyses suggest that low glucose activates background cationic Na+-permeant channels, possibly of the transient receptor potential C subtype. Rotenone, a drug that occludes glomus cell sensitivity to hypoxia, did not abolish responsiveness to low glucose. The association of Glut2 and glucokinase, characteristic of some high glucose\u2013sensing cells, did not seem to be needed for low glucose detection.<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014Altogether, these data support the view that the CB is a multimodal chemoreceptor with a physiological role in glucose homeostasis.<\/jats:p>","DOI":"10.2337\/db07-0122","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T00:54:09Z","timestamp":1189212849000},"page":"2893-2900","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":85,"title":["Mechanisms of Low-Glucose Sensitivity in Carotid Body Glomus Cells"],"prefix":"10.2337","volume":"56","author":[{"given":"Mari\u0301a","family":"Garci\u0301a-Ferna\u0301ndez","sequence":"first","affiliation":[{"name":"From the Laboratorio de Investigaciones Biome\u0301dicas, Departamento de Fisiologi\u0301a Me\u0301dica y Biofi\u0301sica, and Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ortega-Sa\u0301enz","sequence":"additional","affiliation":[{"name":"From the Laboratorio de Investigaciones Biome\u0301dicas, Departamento de Fisiologi\u0301a Me\u0301dica y Biofi\u0301sica, and Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Castellano","sequence":"additional","affiliation":[{"name":"From the Laboratorio de Investigaciones Biome\u0301dicas, Departamento de Fisiologi\u0301a Me\u0301dica y Biofi\u0301sica, and Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301","family":"Lo\u0301pez-Barneo","sequence":"additional","affiliation":[{"name":"From the Laboratorio de Investigaciones Biome\u0301dicas, Departamento de Fisiologi\u0301a Me\u0301dica y Biofi\u0301sica, and Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207544573000_R1","doi-asserted-by":"crossref","unstructured":"Cryer PE: Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. 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