{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:08:05Z","timestamp":1787620085000,"version":"build-2736575974"},"reference-count":49,"publisher":"American Diabetes Association","issue":"12","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Pregnant diabetic women are at a 4\u201312 times higher risk for preeclampsia, an urgent acute-onset complication of mid- to late gestation, than normal pregnant women. Hallmarks of preeclampsia are hypertension, proteinuria, and incomplete modification of endometrial spiral arteries. Transient proangiogenic lymphocytes called uterine natural killer (uNK) cells are implicated in human and rodent spiral artery modification. We studied mid- to late gestations in spontaneously type 1 diabetic NOD mice to investigate whether diabetes alters uNK cell homing and\/or function.<\/jats:p><jats:p>RESEARCH DESIGN AND METHODS\u2014Normoglycemic, pre-diabetic, and diabetic NOD mice and controls were mated. Lymphocytes and endometrial endothelium and decidua were studied histologically and in functional assays.<\/jats:p><jats:p>RESULTS\u2014Conception accelerated progression to overt diabetes in NOD females who had limited spiral artery development, heavier placentas, and lighter fetuses displaying numerous birth defects compared with controls. UNK cell numbers were reduced in the decidua basalis of diabetic females, whereas interferon-\u03b3 production was elevated. In diabetic NOD mice, decidual expression of the mucosal vascular addressin cell adhesion molecule (MAdCAM)-1 was aberrant in position, whereas vascular cell adhesion molecule (VCAM)-1 expression was reduced. Assays of lymphocyte adhesion to tissue sections under shear forces indicated that diabetes compromises the potential homing functions of both endometrial endothelium and peripheral NK cells.<\/jats:p><jats:p>CONCLUSIONS\u2014In diabetes, gestational endometrium has immune and vascular defects that likely contribute to murine fetal loss and birth defects. Analogous problems and preeclampsia in diabetic women may involve similar mechanisms.<\/jats:p>","DOI":"10.2337\/db07-0773","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T00:54:09Z","timestamp":1189212849000},"page":"2919-2926","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice"],"prefix":"10.2337","volume":"56","author":[{"given":"Suzanne D.","family":"Burke","sequence":"first","affiliation":[{"name":"From the Department of Anatomy and Cell Biology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Dong","sequence":"additional","affiliation":[{"name":"From the Department of Anatomy and Cell Biology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleah D.","family":"Hazan","sequence":"additional","affiliation":[{"name":"From the Department of Anatomy and Cell Biology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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