{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:31:53Z","timestamp":1765294313672,"version":"3.35.0"},"reference-count":38,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes.<\/jats:p><jats:p>RESEARCH DESIGN AND METHODS\u2014We examined the effects of sulfasalazine, salicylates, and the poly(ADP-ribose) polymerase-1 inhibitor PJ34 on altered nociception in streptozotocin-induced diabetic rats. We also evaluated the levels of sulfasalazine targets in sciatic nerves and dorsal root ganglia (DRG) of treated animals. Finally, we analyzed the development of tactile allodynia in diabetic mice lacking expression of the sulfasalazine target nuclear factor-\u03baB (NF-\u03baB) p50.<\/jats:p><jats:p>RESULTS\u2014Sulfasalazine completely blocked the development of tactile allodynia in diabetic rats, whereas relatively minor effects were observed with other salicylates and PJ34. Along with the behavioral findings, sciatic nerves and DRG from sulfasalazine-treated diabetic rats displayed a decrease in NF-\u03baB p50 expression compared with untreated diabetic animals. Importantly, the absence of tactile allodynia in diabetic NF-\u03baB p50\u2212\/\u2212 mice supported a role for NF-\u03baB in diabetic neuropathy. Sulfasalazine treatment also increased inosine levels in sciatic nerves of diabetic rats.<\/jats:p><jats:p>CONCLUSIONS\u2014The complete inhibition of tactile allodynia in experimental diabetes by sulfasalazine may stem from its ability to regulate both NF-\u03baB and inosine. Sulfasalazine might be useful in the treatment of nociceptive alterations in diabetic patients.<\/jats:p>","DOI":"10.2337\/db07-1274","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T04:18:47Z","timestamp":1216181927000},"page":"2801-2808","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":29,"title":["Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats"],"prefix":"10.2337","volume":"57","author":[{"given":"Liliana N.","family":"Berti-Mattera","sequence":"first","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy S.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio"},{"name":"Veterans Administration Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Nemet","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochanda","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031208271257300_R1","doi-asserted-by":"crossref","unstructured":"Vinik AI, Park TS, Stansberry KB, Pittenger GL: Diabetic neuropathies. 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