{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:38:18Z","timestamp":1791095898073,"version":"4.1.0"},"reference-count":30,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>OBJECTIVE\u2014Uncoupling protein 2 (UCP2) is a physiological downregulator of reactive oxygen species generation and plays an antiatherogenic role in the vascular wall. A common variant in the UCP2 promoter (\u2212866G&amp;gt;A) modulates mRNA expression, with increased expression associated with the A allele. We investigated association of this variant with coronary artery disease (CAD) in two cohorts of type 2 diabetic subjects.<\/jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014We studied 3,122 subjects from the 6-year prospective Non\u2013Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events, and Ramipril (DIABHYCAR) Study (14.9% of CAD incidence at follow-up). An independent, hospital-based cohort of 335 men, 52% of whom had CAD, was also studied.<\/jats:p>\n               <jats:p>RESULTS\u2014We observed an inverse association of the A allele with incident cases of CAD in a dominant model (hazard risk 0.88 [95% CI 0.80\u20130.96]; P = 0.006). Similar results were observed for baseline cases of CAD. Stratification by sex confirmed an allelic association with CAD in men, whereas no association was observed in women. All CAD phenotypes considered\u2014myocardial infarction, angina pectoris, coronary artery bypass graft (CABG), and sudden death\u2014contributed significantly to the association. Results were replicated in a cross-sectional study of an independent cohort (odds ratio 0.47 [95% CI 0.25\u20130.89]; P = 0.02 for a recessive model).<\/jats:p>\n               <jats:p>CONCLUSIONS\u2014The A allele of the \u2212866G&amp;gt;A variant of UCP2 was associated with reduced risk of CAD in men with type 2 diabetes in a 6-year prospective study. Decreased risk of myocardial infarction, angina pectoris, CABG, and sudden death contributed individually and significantly to the reduction of CAD risk. This association was independent of other common CAD risk factors.<\/jats:p>","DOI":"10.2337\/db07-1292","type":"journal-article","created":{"date-parts":[[2008,1,12]],"date-time":"2008-01-12T02:09:36Z","timestamp":1200103776000},"page":"1063-1068","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":40,"title":["The Common \u2212866G&amp;gt;A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men"],"prefix":"10.2337","volume":"57","author":[{"given":"Nadir","family":"Cheurfa","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danie\u0300le","family":"Dubois-Laforgue","sequence":"additional","affiliation":[{"name":"Department of Immunology and Diabetology, AP-HP Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela A.F.","family":"Ferrarezi","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"},{"name":"Laboratory of Cellular and Molecular Endocrinology, Sa\u0303o Paulo University, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301 F.","family":"Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Endocrinology, Federal University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme M.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"},{"name":"Post-Graduation Program in Medical Sciences, Federal Faculty Foundation of Medical Sciences of Porto Alegre, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bouche\u0301","sequence":"additional","affiliation":[{"name":"Department of Immunology and Diabetology, AP-HP Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Le Feuvre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Assistance Publique\u2013Ho\u0302pitaux de Paris, La Pitie\u0301 Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Fumeron","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"},{"name":"Universite\u0301 Denis Diderot Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301","family":"Timsit","sequence":"additional","affiliation":[{"name":"Department of Immunology and Diabetology, AP-HP Cochin Hospital, Paris, France"},{"name":"Universite\u0301 Rene\u0301 Descartes Paris 5, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Marre","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"},{"name":"Universite\u0301 Denis Diderot Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Velho","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Research Unit 695, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031208315352200_R1","doi-asserted-by":"crossref","unstructured":"Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. 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