{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:00:34Z","timestamp":1790676034475,"version":"4.1.0"},"reference-count":41,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":4440,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\u03b2-Cell mass declines progressively during the course of diabetes, and various antidiabetic treatment regimens have been suggested to modulate \u03b2-cell mass. However, imaging methods allowing the monitoring of changes in \u03b2-cell mass in vivo have not yet become available. We address whether pancreatic \u03b2-cell area can be assessed by functional test of insulin secretion in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A total of 33 patients with chronic pancreatitis (n = 17), benign pancreatic adenomas (n = 13), and tumors of the ampulla of Vater (n = 3) at various stages of glucose tolerance were examined with an oral glucose load before undergoing pancreatic surgery. Indexes of insulin secretion were calculated and compared with the fractional \u03b2-cell area of the pancreas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\u03b2-Cell area was related to fasting glucose concentrations in an inverse linear fashion (r = \u22120.53, P = 0.0014) and to 120-min postchallenge glycemia in an inverse exponential fashion (r = \u22120.89). \u03b2-Cell area was best predicted by a C-peptide\u2013to\u2013glucose ratio determined 15 min after the glucose drink (r = 0.72, P &amp;lt; 0.0001). However, a fasting C-peptide\u2013to\u2013glucose ratio already yielded a reasonably close correlation (r = 0.63, P &amp;lt; 0.0001). Homeostasis model assessment (HOMA) \u03b2-cell function was unrelated to \u03b2-cell area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Glucose control is closely related to pancreatic \u03b2-cell area in humans. A C-peptide\u2013to\u2013glucose ratio after oral glucose ingestion appears to better predict \u03b2-cell area than fasting measures, such as the HOMA index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db08-1611","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T23:44:10Z","timestamp":1244591050000},"page":"1595-1603","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":138,"title":["Functional Assessment of Pancreatic \u03b2-Cell Area in Humans"],"prefix":"10.2337","volume":"58","author":[{"given":"Juris J.","family":"Meier","sequence":"first","affiliation":[{"name":"Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern A.","family":"Menge","sequence":"additional","affiliation":[{"name":"Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.K.","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. Josef-Hospital, Ruhr-University Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tannapfel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ruhr-University Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. Josef-Hospital, Ruhr-University Bochum, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang 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