{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:13:28Z","timestamp":1791227608147,"version":"4.1.0"},"reference-count":47,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":4467,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>An increased expression of RELM-\u03b2 (resistin-like molecule-\u03b2), a gut-derived hormone, is observed in animal models of insulin resistance\/obesity and intestinal inflammation. Intestinal sugar absorption is modulated by dietary environment and hormones\/cytokines. The aim of this study was to investigate the effect of RELM-\u03b2 on intestinal glucose absorption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Oral glucose tolerance test was performed in mice and rats in the presence and the absence of RELM-\u03b2. The RELM-\u03b2 action on glucose transport in rat jejunal sacs, everted rings, and mucosal strips was explored as well as downstream kinases modulating SGLT-1 and GLUT2 glucose transporters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Oral glucose tolerance test carried out in rodents showed that oral administration of RELM-\u03b2 increased glycemia. Studies in rat jejunal tissue indicated that mucosal RELM-\u03b2 promoted absorption of glucose from the gut lumen. RELM-\u03b2 had no effect on paracellular mannitol transport, suggesting a transporter-mediated transcellular mechanism. In studies with jejunal mucosa mounted in Ussing chamber, luminal RELM-\u03b2 inhibited SGLT-1 activity in line with a diminished SGLT-1 abundance in brush border membranes (BBMs). Further, the potentiating effect of RELM-\u03b2 on jejunal glucose uptake was associated with an increased abundance of GLUT2 at BBMs. The effects of RELM-\u03b2 were associated with an increased amount of protein kinase C \u03b2II in BBMs and an increased phosphorylation of AMP-activated protein kinase (AMPK).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The regulation of SGLT-1 and GLUT2 by RELM-\u03b2 expands the role of gut hormones in short-term AMPK\/protein kinase C mediated control of energy balance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/db08-1786","type":"journal-article","created":{"date-parts":[[2009,6,6]],"date-time":"2009-06-06T01:00:28Z","timestamp":1244250028000},"page":"2032-2038","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":36,"title":["Resistin-Like Molecule-\u03b2 Inhibits SGLT-1 Activity and Enhances GLUT2-Dependent Jejunal Glucose Transport"],"prefix":"10.2337","volume":"58","author":[{"given":"Rim Belharbi","family":"Krimi","sequence":"first","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Letteron","sequence":"additional","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Chedid","sequence":"additional","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Nazaret","sequence":"additional","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ducroc","sequence":"additional","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Marie","sequence":"additional","affiliation":[{"name":"From INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, and Universit\u00e9 Paris 7 Denis Diderot, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"2022031215552164500_B1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to 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