{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:57:18Z","timestamp":1791424638101,"version":"4.3.3"},"reference-count":20,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":3843,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3\u2032-UTR of IKZF1 with C-ALL susceptibility, we tested whether IKZF1 is associated with the autoimmune disease type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>rs10272724 (T&amp;gt;C) near IKZF1 at 7p12 was genotyped in 8,333 individuals with type 1 diabetes, 9,947 control subjects, and 3,997 families of European ancestry. Association was tested using logistic regression in the case-control data and by the transmission disequilibrium test in the families. Expression data for IKZF1 by rs10272724 genotype were obtained using quantitative PCR of mRNA\/cDNA generated from peripheral blood mononuclear cells from 88 individuals, whereas expression data for five other neighboring genes were obtained from the online Genevar dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The minor allele of rs10272724 (C) was found to be protective from type 1 diabetes (odds ratio 0.87 [95% CI 0.83\u20130.91]; P = 1.1 \u00d7 10\u221211). rs10272724 was not correlated with levels of two transcripts of IKZF1 in peripheral blood mononuclear cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The major susceptibility genotype for C-ALL confers protection from type 1 diabetes. Our finding strengthens the link between autoimmunity and lymphoid cancers. Further investigation is warranted for the genetic effect marked by rs10272724, its impact on IKZF1, and the role of Ikaros and other family members, Ailios (IKZF3) and Eos (IKZF4), in autoimmunity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/db10-0446","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T21:44:01Z","timestamp":1296078241000},"page":"1041-1044","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":55,"title":["An Allele of\n                    <i>IKZF1<\/i>\n                    (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes"],"prefix":"10.2337","volume":"60","author":[{"given":"Austin D.-E.","family":"Swafford","sequence":"first","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."},{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.M.","family":"Howson","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy J.","family":"Davison","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Wallace","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Schuilenburg","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meeta","family":"Maisuria-Armer","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Mistry","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lenardo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Todd","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2011,2,21]]},"reference":[{"key":"2022031223355668200_B1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1084\/jem.190.8.1039","article-title":"Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros","volume":"190","author":"Winandy","year":"1999","journal-title":"J Exp Med"},{"key":"2022031223355668200_B2","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.4049\/jimmunol.0901284","article-title":"Ikaros is a regulator of Il10 expression in CD4+ T 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