{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:52:10Z","timestamp":1781664730956,"version":"3.54.5"},"reference-count":18,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":3843,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"DOI":"10.2337\/db10-1667","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T22:37:27Z","timestamp":1298673447000},"page":"695-696","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":38,"title":["Learning From Glycosuria"],"prefix":"10.2337","volume":"60","author":[{"given":"Ele","family":"Ferrannini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2011,2,21]]},"reference":[{"key":"2022031223335465500_B1"},{"key":"2022031223335465500_B2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/physrev.1994.74.4.993","article-title":"Molecular physiology of sodium-glucose cotransporters","volume":"74","author":"Hediger","year":"1994","journal-title":"Physiol Rev"},{"key":"2022031223335465500_B3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1124\/jpet.107.129825","article-title":"Inhibitor binding in the human renal low- and high-affinity Na+\/glucose cotransporters","volume":"324","author":"Pajor","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"2022031223335465500_B4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1172\/JCI102424","article-title":"Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose","volume":"30","author":"Farber","year":"1951","journal-title":"J Clin Invest"},{"key":"2022031223335465500_B5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/00365517109090668","article-title":"Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects","volume":"28","author":"Mogensen","year":"1971","journal-title":"Scand J Clin Lab Invest"},{"key":"2022031223335465500_B6","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.2337\/diabetes.54.12.3427","article-title":"Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes","volume":"54","author":"Rahmoune","year":"2005","journal-title":"Diabetes"},{"key":"2022031223335465500_B7","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1097\/01.ASN.0000092790.89332.D2","article-title":"Molecular analysis of the SGLT2 gene in patients with renal glucosuria","volume":"14","author":"Santer","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"2022031223335465500_B8","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1172\/JCI112981","article-title":"Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats","volume":"79","author":"Rossetti","year":"1987","journal-title":"J Clin Invest"},{"key":"2022031223335465500_B9"},{"key":"2022031223335465500_B10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/clpt.2008.251","article-title":"Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects","volume":"85","author":"Komoroski","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"2022031223335465500_B11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/clpt.2008.250","article-title":"Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus","volume":"85","author":"Komoroski","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"2022031223335465500_B12","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.2337\/dc09-0517","article-title":"A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment","volume":"32","author":"Wilding","year":"2009","journal-title":"Diabetes Care"},{"key":"2022031223335465500_B13","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.2337\/dc10-0612","article-title":"Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial","volume":"33","author":"Ferrannini","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031223335465500_B14","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(10)60407-2","article-title":"Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial","volume":"375","author":"Bailey","year":"2010","journal-title":"Lancet"},{"key":"2022031223335465500_B15"},{"key":"2022031223335465500_B16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/jm701272q","article-title":"Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes","volume":"51","author":"Meng","year":"2008","journal-title":"J Med Chem"},{"key":"2022031223335465500_B17","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm0410-392","article-title":"Neuronal regulation of homeostasis by nutrient sensing","volume":"16","author":"Lam","year":"2010","journal-title":"Nat Med"},{"key":"2022031223335465500_B18"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/60\/3\/695\/399887\/695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/60\/3\/695\/399887\/695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:25:37Z","timestamp":1667406337000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/60\/3\/695\/33525\/Learning-From-Glycosuria"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,21]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,2,21]]},"published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db10-1667","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,21]]}}}