{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:44:52Z","timestamp":1790667892939,"version":"4.1.0"},"reference-count":50,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":3270,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>Adipose-derived mesenchymal stem cells (ADMSCs) display immunosuppressive properties, suggesting a promising therapeutic application in several autoimmune diseases, but their role in type 1 diabetes (T1D) remains largely unexplored. The aim of this study was to investigate the immune regulatory properties of allogeneic ADMSC therapy in T cell\u2013mediated autoimmune diabetes in NOD mice. ADMSC treatment reversed the hyperglycemia of early-onset diabetes in 78% of diabetic NOD mice, and this effect was associated with higher serum insulin, amylin, and glucagon-like peptide 1 levels compared with untreated controls. This improved outcome was associated with downregulation of the CD4+ Th1-biased immune response and expansion of regulatory T cells (Tregs) in the pancreatic lymph nodes. Within the pancreas, inflammatory cell infiltration and interferon-\u03b3 levels were reduced, while insulin, pancreatic duodenal homeobox-1, and active transforming growth factor-\u03b21 expression were increased. In vitro, ADMSCs induced the expansion\/proliferation of Tregs in a cell contact\u2013dependent manner mediated by programmed death ligand 1. In summary, ADMSC therapy efficiently ameliorates autoimmune diabetes pathogenesis in diabetic NOD mice by attenuating the Th1 immune response concomitant with the expansion\/proliferation of Tregs, thereby contributing to the maintenance of functional \u03b2-cells. Thus, this study may provide a new perspective for the development of ADMSC-based cellular therapies for T1D.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/db11-0844","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T05:59:02Z","timestamp":1339480742000},"page":"2534-2545","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":135,"title":["Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes"],"prefix":"10.2337","volume":"61","author":[{"given":"\u00canio J.","family":"Bassi","sequence":"first","affiliation":[{"name":"Department of Immunology, Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences IV, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro 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