{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:23:06Z","timestamp":1791238986182,"version":"4.1.0"},"reference-count":54,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":3510,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>More than one-half of the ~50 human chemokines have been associated with or implicated in the pathogenesis of type 1 diabetes, yet their actual expression patterns in the islet environment of type 1 diabetic patients remain, at present, poorly defined. Here, we have integrated a human islet culture system, murine models of virus-induced and spontaneous type 1 diabetes, and the histopathological examination of pancreata from diabetic organ donors with the goal of providing a foundation for the informed selection of potential therapeutic targets within the chemokine\/receptor family. Chemokine (C-C motif) ligand (CCL) 5 (CCL5), CCL8, CCL22, chemokine (C-X-C motif) ligand (CXCL) 9 (CXCL9), CXCL10, and chemokine (C-X3-C motif) ligand (CX3CL) 1 (CX3CL1) were the major chemokines transcribed (in an inducible nitric oxide synthase\u2013dependent but not nuclear factor-\u03baB\u2013dependent fashion) and translated by human islet cells in response to in vitro inflammatory stimuli. CXCL10 was identified as the dominant chemokine expressed in vivo in the islet environment of prediabetic animals and type 1 diabetic patients, whereas CCL5, CCL8, CXCL9, and CX3CL1 proteins were present at lower levels in the islets of both species. Of importance, additional expression of the same chemokines in human acinar tissues emphasizes an underappreciated involvement of the exocrine pancreas in the natural course of type 1 diabetes that will require consideration for additional type 1 diabetes pathogenesis and immune intervention studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/db11-0853","type":"journal-article","created":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T01:31:12Z","timestamp":1325295072000},"page":"436-446","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":132,"title":["Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes"],"prefix":"10.2337","volume":"61","author":[{"given":"Suparna A.","family":"Sarkar","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Victorino","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"},{"name":"Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A.","family":"Walters","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Burrack","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"},{"name":"Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Eberlein","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Hildemann","sequence":"additional","affiliation":[{"name":"Innere Medizin III, Unversit\u00e4tsklinik Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Homann","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado"},{"name":"Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, Colorado"},{"name":"Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"2022031208585713600_B1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/gb-2006-7-12-243","article-title":"The chemokine and chemokine receptor superfamilies and their molecular evolution","volume":"7","author":"Zlotnik","year":"2006","journal-title":"Genome Biol"},{"key":"2022031208585713600_B2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1146\/annurev.immunol.22.012703.104543","article-title":"Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells","volume":"22","author":"Rot","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"2022031208585713600_B3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1034\/j.1600-065X.2003.00067.x","article-title":"Chemokines in the systemic organization of immunity","volume":"195","author":"Campbell","year":"2003","journal-title":"Immunol Rev"},{"key":"2022031208585713600_B4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/er.2006-0044","article-title":"Role of chemokines in endocrine autoimmune diseases","volume":"28","author":"Rotondi","year":"2007","journal-title":"Endocr Rev"},{"key":"2022031208585713600_B5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/187153007780059405","article-title":"Chemokines as drug targets in type 1 diabetes","volume":"7","author":"Christen","year":"2007","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"2022031208585713600_B6","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1056\/NEJMoa0807917","article-title":"Shared and distinct genetic variants in type 1 diabetes and celiac disease","volume":"359","author":"Smyth","year":"2008","journal-title":"N Engl J Med"},{"key":"2022031208585713600_B7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2010.04.001","article-title":"Etiology of type 1 diabetes","volume":"32","author":"Todd","year":"2010","journal-title":"Immunity"},{"key":"2022031208585713600_B8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2009.21","article-title":"The role of inflammation in insulitis and beta-cell loss in type 1 diabetes","volume":"5","author":"Eizirik","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"2022031208585713600_B9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1586\/14737159.6.1.51","article-title":"Quantification of chemokines by real-time reverse transcriptase PCR: applications in type 1 diabetes","volume":"6","author":"Overbergh","year":"2006","journal-title":"Expert Rev Mol Diagn"},{"key":"2022031208585713600_B10","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.4049\/jimmunol.0803348","article-title":"Selective autoantibody production against CCL3 is associated with human type 1 diabetes mellitus and serves as a novel biomarker for its diagnosis","volume":"182","author":"Shehadeh","year":"2009","journal-title":"J Immunol"},{"key":"2022031208585713600_B11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1464-5491.2005.01743.x","article-title":"Altered chemokine levels in individuals at risk of type 1 diabetes mellitus","volume":"23","author":"Hanifi-Moghaddam","year":"2006","journal-title":"Diabet Med"},{"key":"2022031208585713600_B12","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.4049\/jimmunol.179.9.5760","article-title":"Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1","volume":"179","author":"Cantor","year":"2007","journal-title":"J Immunol"},{"key":"2022031208585713600_B13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2337\/db07-1309","article-title":"Islet expression of M3 uncovers a key role for chemokines in the development and recruitment of diabetogenic cells in NOD mice","volume":"57","author":"Martin","year":"2008","journal-title":"Diabetes"},{"key":"2022031208585713600_B14","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.2337\/db08-0625","article-title":"Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes","volume":"57","author":"Martin","year":"2008","journal-title":"Diabetes"},{"key":"2022031208585713600_B15","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.4049\/jimmunol.165.2.1102","article-title":"Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes","volume":"165","author":"Cameron","year":"2000","journal-title":"J Immunol"},{"key":"2022031208585713600_B16","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/eji.200324285","article-title":"Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice","volume":"34","author":"Carvalho-Pinto","year":"2004","journal-title":"Eur J Immunol"},{"key":"2022031208585713600_B17","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1172\/JCI0215547","article-title":"CCR4-bearing T cells participate in autoimmune diabetes","volume":"110","author":"Kim","year":"2002","journal-title":"J Clin Invest"},{"key":"2022031208585713600_B18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm1202-792","article-title":"Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis","volume":"8","author":"Frigerio","year":"2002","journal-title":"Nat Med"},{"key":"2022031208585713600_B19","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.4049\/jimmunol.171.12.6838","article-title":"Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease","volume":"171","author":"Christen","year":"2003","journal-title":"J Immunol"},{"key":"2022031208585713600_B20","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.4049\/jimmunol.175.6.3516","article-title":"Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development","volume":"175","author":"Rhode","year":"2005","journal-title":"J Immunol"},{"key":"2022031208585713600_B21","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.4049\/jimmunol.173.11.7017","article-title":"CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis","volume":"173","author":"Morimoto","year":"2004","journal-title":"J Immunol"},{"key":"2022031208585713600_B22","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.4049\/jimmunol.175.12.8401","article-title":"CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice","volume":"175","author":"Shigihara","year":"2005","journal-title":"J Immunol"},{"key":"2022031208585713600_B23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaut.2005.09.027","article-title":"Significance of serum CXCL10\/IP-10 level in type 1 diabetes","volume":"26","author":"Shigihara","year":"2006","journal-title":"J Autoimmun"},{"key":"2022031208585713600_B24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2337\/db06-0617","article-title":"Induction of indoleamine 2,3-dioxygenase by interferon-\u03b3 in human islets","volume":"56","author":"Sarkar","year":"2007","journal-title":"Diabetes"},{"key":"2022031208585713600_B25","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1007\/s00125-009-1331-x","article-title":"Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line","volume":"52","author":"Sarkar","year":"2009","journal-title":"Diabetologia"},{"key":"2022031208585713600_B26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1172\/JCI40645","article-title":"Comprehensive assessment of chemokine expression profiles by flow cytometry","volume":"120","author":"Eberlein","year":"2010","journal-title":"J Clin Invest"},{"key":"2022031208585713600_B27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1074-7613(02)00290-X","article-title":"CD40L blockade prevents autoimmune diabetes by induction of bitypic NK\/DC regulatory cells","volume":"16","author":"Homann","year":"2002","journal-title":"Immunity"},{"key":"2022031208585713600_B28","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.1128\/JVI.72.11.9208-9216.1998","article-title":"Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT\/muMT mice","volume":"72","author":"Homann","year":"1998","journal-title":"J Virol"},{"key":"2022031208585713600_B29","doi-asserted-by":"crossref","first-page":"14759","DOI":"10.1073\/pnas.0702229104","article-title":"Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12\/SDF-1 receptor, CXCR7","volume":"104","author":"Sierro","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022031208585713600_B30","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00125-008-0999-7","article-title":"Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells","volume":"51","author":"Ortis","year":"2008","journal-title":"Diabetologia"},{"key":"2022031208585713600_B31","first-page":"407","article-title":"iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis","volume-title":"Mol Pharm","author":"Li","year":"2008"},{"key":"2022031208585713600_B32","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/db09-0091","article-title":"Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated \u03b2-cell failure in fulminant type 1 diabetes","volume":"58","author":"Tanaka","year":"2009","journal-title":"Diabetes"},{"key":"2022031208585713600_B33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1507\/endocrj.K10E-076","article-title":"Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes","volume":"57","author":"Uno","year":"2010","journal-title":"Endocr J"},{"key":"2022031208585713600_B34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/0891693021000041088","article-title":"CCR5 genotyping in an Australian and New Zealand type 1 diabetes cohort","volume":"35","author":"Buhler","year":"2002","journal-title":"Autoimmunity"},{"key":"2022031208585713600_B35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1203\/00006450-199907000-00014","article-title":"Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus","volume":"46","author":"Szalai","year":"1999","journal-title":"Pediatr Res"},{"key":"2022031208585713600_B36","first-page":"3024","article-title":"Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets","volume-title":"J Clin Invest","author":"Montane","year":"2011"},{"key":"2022031208585713600_B37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"2022031208585713600_B38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1517\/14728220903540265","article-title":"Fractalkine\/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential","volume":"14","author":"D\u2019Haese","year":"2010","journal-title":"Expert Opin Ther Targets"},{"key":"2022031208585713600_B39","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2249.2009.04087.x","article-title":"Islet inflammation and CXCL10 in recent-onset type 1 diabetes","volume":"159","author":"Roep","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"2022031208585713600_B40","first-page":"125","article-title":"CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling","volume-title":"Cell Metab","author":"Schulthess","year":"2009"},{"key":"2022031208585713600_B41","first-page":"318","article-title":"Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model","volume-title":"Clin Exp Immunol","author":"Christen","year":"2011"},{"key":"2022031208585713600_B42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BST0360321","article-title":"Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes","volume":"36","author":"Eizirik","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"2022031208585713600_B43","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00125-010-1849-y","article-title":"Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients","volume":"53","author":"Pugazhenthi","year":"2010","journal-title":"Diabetologia"},{"key":"2022031208585713600_B44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nrmicro2541","article-title":"Genome-virome interactions: examining the role of common viral infections in complex disease","volume":"9","author":"Foxman","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"2022031208585713600_B45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000085264","article-title":"Endocrine pancreatic insufficiency in chronic pancreatitis","volume":"5","author":"Angelopoulos","year":"2005","journal-title":"Pancreatology"},{"key":"2022031208585713600_B46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJM200002033420501","article-title":"A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies","volume":"342","author":"Imagawa","year":"2000","journal-title":"N Engl J Med"},{"key":"2022031208585713600_B47","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJM200006153422413","article-title":"A novel subtype of type 1 diabetes mellitus","volume":"342","author":"Tanaka","year":"2000","journal-title":"N Engl J Med"},{"key":"2022031208585713600_B48","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2337\/db10-0795","article-title":"RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates \u03b2-cell death in fulminant type 1 diabetes","volume":"60","author":"Aida","year":"2011","journal-title":"Diabetes"},{"key":"2022031208585713600_B49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11894-005-0047-4","article-title":"Autoimmune pancreatitis","volume":"7","author":"Lara","year":"2005","journal-title":"Curr Gastroenterol Rep"},{"key":"2022031208585713600_B50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/187152810791292881","article-title":"The role of pro-inflammatory molecules and pharmacological agents in acute pancreatitis and sepsis","volume":"9","author":"Shanmugam","year":"2010","journal-title":"Inflamm Allergy Drug Targets"},{"key":"2022031208585713600_B51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00535-006-1929-4","article-title":"Can measurement of chemokines become useful biological and functional markers of early-stage chronic pancreatitis?","volume":"42","author":"Ito","year":"2007","journal-title":"J Gastroenterol"},{"key":"2022031208585713600_B52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1159\/000108965","article-title":"Expression of interferon-gamma- inducible protein-10 and its receptor CXCR3 in chronic pancreatitis","volume":"7","author":"Singh","year":"2007","journal-title":"Pancreatology"},{"key":"2022031208585713600_B53","doi-asserted-by":"crossref","first-page":"G345","DOI":"10.1152\/ajpgi.00002.2006","article-title":"Role of IP-10\/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection","volume":"291","author":"Kawauchi","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2022031208585713600_B54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2010.08.001","article-title":"Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery","volume":"133","author":"Planas","year":"2010","journal-title":"Immunol Lett"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/61\/2\/436\/559592\/436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/61\/2\/436\/559592\/436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:27:36Z","timestamp":1667406456000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/61\/2\/436\/14653\/Expression-and-Regulation-of-Chemokines-in-Murine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,17]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,1,17]]},"published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db11-0853","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,17]]}}}