{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:49:26Z","timestamp":1783518566258,"version":"3.55.0"},"reference-count":40,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":3360,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these changes vary according to the degree of microangiopathy. T1DM patients with (MA+: n = 49) and without (MA\u2212: n = 52) microangiopathy were compared with 48 healthy control subjects. All completed a neuropsychological assessment and resting-state fMRI. Networks were identified using multisubject independent component analysis; specific group differences within each network were analyzed using the dual-regression method, corrected for confounding factors and multiple comparisons. Relative to control subjects, MA\u2212 patients showed increased connectivity in networks involved in motor and visual processes, whereas MA+ patients showed decreased connectivity in networks involving attention, working memory, auditory and language processing, and motor and visual processes. Better information-processing speed and general cognitive ability were related to increased degree of connectivity. T1DM is associated with a functional reorganization of neural networks that varies, dependent on the presence or absence of microangiopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/db11-1358","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T17:59:21Z","timestamp":1332439161000},"page":"1814-1821","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":113,"title":["Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables"],"prefix":"10.2337","volume":"61","author":[{"given":"Eelco","family":"van Duinkerken","sequence":"first","affiliation":[{"name":"Diabetes Center\/Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Diabetes Psychology Research Group\/Department of Medical Psychology, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno M.","family":"Schoonheim","sequence":"additional","affiliation":[{"name":"Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto J.","family":"Sanz-Arigita","sequence":"additional","affiliation":[{"name":"Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Radiology, Centro de Investigaci\u00f3n y Terapias Avanzadas (CITA)-Alzheimer Foundation, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"IJzerman","sequence":"additional","affiliation":[{"name":"Diabetes Center\/Department of Internal Medicine, VU University Medical Center, Amsterdam, the 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