{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:07:52Z","timestamp":1791022072839,"version":"4.1.0"},"reference-count":46,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":3116,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:p>Peripheral neuropathy and insensate limbs and digits cause significant morbidity in diabetic individuals. Previous studies showed that deletion of the receptor for advanced end-glycation products (RAGE) in mice was protective in long-term diabetic neuropathy. Here, we tested the hypothesis that RAGE suppresses effective axonal regeneration in superimposed acute peripheral nerve injury attributable to tissue-damaging inflammatory responses. We report that deletion of RAGE, particularly in diabetic mice, resulted in significantly higher myelinated fiber densities and conduction velocities consequent to acute sciatic nerve crush compared with wild-type control animals. Consistent with key roles for RAGE-dependent inflammation, reconstitution of diabetic wild-type mice with RAGE-null versus wild-type bone marrow resulted in significantly improved axonal regeneration and restoration of function. Diabetic RAGE-null mice displayed higher numbers of invading macrophages in the nerve segments postcrush compared with wild-type animals, and these macrophages in diabetic RAGE-null mice displayed greater M2 polarization. In vitro, treatment of wild-type bone marrow\u2013derived macrophages with advanced glycation end products (AGEs), which accumulate in diabetic nerve tissue, increased M1 and decreased M2 gene expression in a RAGE-dependent manner. Blockade of RAGE may be beneficial in the acute complications of diabetic neuropathy, at least in part, via upregulation of regeneration signals.<\/jats:p>","DOI":"10.2337\/db12-0632","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T06:50:48Z","timestamp":1353394248000},"page":"931-943","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":85,"title":["RAGE Deficiency Improves Postinjury Sciatic Nerve Regeneration in Type 1 Diabetic Mice"],"prefix":"10.2337","volume":"62","author":[{"given":"Judyta K.","family":"Juranek","sequence":"first","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Geddis","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"},{"name":"Department of Science, Borough of Manhattan Community College\u2013City University of New York, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Song","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rosario","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Brannagan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"2022031210110505300_B1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"2022031210110505300_B2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"},{"key":"2022031210110505300_B3","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2522\/ptj.20080020","article-title":"Epidemiology of diabetes and diabetes-related complications","volume":"88","author":"Deshpande","year":"2008","journal-title":"Phys Ther"},{"key":"2022031210110505300_B4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jdiacomp.2006.08.002","article-title":"Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy","volume":"21","author":"Candrilli","year":"2007","journal-title":"J Diabetes Complications"},{"key":"2022031210110505300_B5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/1471-2458-11-564","article-title":"Diabetes in Sub Saharan Africa 1999-2011: epidemiology and public health implications. 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