{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T07:48:17Z","timestamp":1776584897459,"version":"3.51.2"},"reference-count":50,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":3089,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>We studied the effects of chronic angiotensin 1-7 (Ang 1-7) treatment in an experimental model of the metabolic syndrome, i.e., rats given high-fructose\/low-magnesium diet (HFrD). Rats were fed on HFrD for 24 weeks with and without Ang 1-7 (576 \u00b5g\/kg\/day, s.c., Alzet pumps). After 6 months, Ang 1-7\u2013treated animals had lower body weight (\u22129.5%), total fat mass (detected by magnetic resonance imaging), and serum triglycerides (\u221251%), improved glucose tolerance, and better insulin sensitivity. Similar metabolic effects were also evident, albeit in the absence of weight loss, in rats first exposed to HFrD for 5 months and then subjected to short-term (4 weeks) treatment with Ang 1-7. Six months of Ang 1-7 treatment were associated with lower plasma renin activity (\u221240%) and serum aldosterone (\u221248%), less hepatosteatatitis, and a reduction in epididymal adipocyte volume. The marked attenuation of macrophage infiltration in white adipose tissue (WAT) was associated with reduced levels of the pP65 protein in the epididymal fat tissue, suggesting less activation of the nuclear factor-\u03baB (NF\u03baB) pathway in Ang 1-7\u2013treated rats. WAT from Ang 1-7\u2013treated rats showed reduced NADPH-stimulated superoxide production. In single muscle fibers (myofibers) harvested and grown ex vivo for 10 days, myofibers from HFrD rats gave rise to 20% less myogenic cells than the Ang 1-7\u2013treated rats. Fully developed adipocytes were present in most HFrD myofiber cultures but entirely absent in cultures from Ang 1-7\u2013treated rats. In summary, Ang 1-7 had an ameliorating effect on insulin resistance, hypertriglyceridemia, fatty liver, obesity, adipositis, and myogenic and adipogenic differentiation in muscle tissue in the HFrD rats.<\/jats:p>","DOI":"10.2337\/db12-0792","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T03:40:47Z","timestamp":1355888447000},"page":"1121-1130","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":69,"title":["Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome"],"prefix":"10.2337","volume":"62","author":[{"given":"Yonit","family":"Marcus","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel"},{"name":"Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, 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