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Based on their 2-h glucose tests they were stratified in the following groups: group 1, 2-h glucose level &amp;lt;120 mg\/dL; group 2, 2-h glucose level between 120 and 140 mg\/dL; and group 3, 2-h glucose level &amp;gt;140 mg\/dL. Liver and adipose tissue insulin sensitivity were greater in group 1 than in group 2 and group 3, and muscle insulin sensitivity progressively decreased from group 1 to group 3. The expression of the carbohydrate-responsive element-binding protein (ChREBP) was decreased in adipose tissue but increased in the liver (eight subjects) in adolescents with impaired glucose tolerance or type 2 diabetes. The expression of adipose ChREBP\u03b1 and ChREBP\u03b2 was inversely related to 2-h glucose level and positively correlated to insulin sensitivity. Improvement of glucose tolerance in four subjects was associated with an increase of ChREBP\/GLUT4 expression in the adipose tissue. In conclusion, early in the development of prediabetes\/type 2 diabetes in youth, ChREBP\u03b2 expression in adipose tissue predicts insulin resistance and, therefore, might play a role in the regulation of glucose tolerance.<\/jats:p>","DOI":"10.2337\/db12-0889","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T07:37:49Z","timestamp":1354606669000},"page":"837-844","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":101,"title":["Decreased Transcription of ChREBP-\u03b1\/\u03b2 Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes"],"prefix":"10.2337","volume":"62","author":[{"given":"Romy","family":"Kursawe","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Caprio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lin","sequence":"additional","affiliation":[{"name":"W.M. 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