{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:20:51Z","timestamp":1791807651408,"version":"4.3.4"},"reference-count":46,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":3089,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>We designed an experiment to examine the effect of bile acid sequestration with Colesevelam on fasting and postprandial glucose metabolism in type 2 diabetes. To do so, we tested the hypothesis that Colesevelam increases the disposition index (DI), and this increase is associated with increased glucagon-like peptide-1 (GLP-1) concentrations. Thirty-eight subjects on metformin monotherapy were studied using a double-blind, placebo-controlled, parallel-group design. Subjects were studied before and after 12 weeks of Colesevelam or placebo using a labeled triple-tracer mixed meal to measure the rate of meal appearance (Meal Ra), endogenous glucose production (EGP), and glucose disappearance (Rd). Insulin sensitivity and \u03b2-cell responsivity indices were estimated using the oral minimal model and then used to calculate DI. Therapy with Colesevelam was associated with a decrease in fasting (7.0 \u00b1 0.2 vs. 6.6 \u00b1 0.2 mmol\/L; P = 0.004) and postprandial glucose concentrations (3,145 \u00b1 138 vs. 2,896 \u00b1 127 mmol\/6 h; P = 0.01) in the absence of a change in insulin concentrations. Minimal model\u2013derived indices of insulin secretion and action were unchanged. Postprandial GLP-1 concentrations were not altered by Colesevelam. Although EGP and Rd were unchanged, integrated Meal Ra was decreased by Colesevelam (5,191 \u00b1 204 vs. 5,817 \u00b1 204 \u03bcmol\/kg\/6 h; P = 0.04), suggesting increased splanchnic sequestration of meal-derived glucose.<\/jats:p>","DOI":"10.2337\/db12-0923","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T03:40:47Z","timestamp":1355888447000},"page":"1094-1101","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":83,"title":["The Effect of a Bile Acid Sequestrant on Glucose Metabolism in Subjects With Type 2 Diabetes"],"prefix":"10.2337","volume":"62","author":[{"given":"Galina","family":"Smushkin","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, 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