{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:33:56Z","timestamp":1791052436669,"version":"4.1.0"},"reference-count":36,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":2844,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p>It is generally accepted that vascularization and oxygenation of pancreatic islets are essential for the maintenance of an optimal \u03b2-cell mass and function and that signaling by vascular endothelial growth factor (VEGF) is crucial for pancreas development, insulin gene expression\/secretion, and (compensatory) \u03b2-cell proliferation. A novel mouse model was designed to allow conditional production of human sFlt1 by \u03b2-cells in order to trap VEGF and study the effect of time-dependent inhibition of VEGF signaling on adult \u03b2-cell fate and metabolism. Secretion of sFlt1 by adult \u03b2-cells resulted in a rapid regression of blood vessels and hypoxia within the islets. Besides blunted insulin release, \u03b2-cells displayed a remarkable capacity for coping with these presumed unfavorable conditions: even after prolonged periods of blood vessel ablation, basal and stimulated blood glucose levels were only slightly increased, while \u03b2-cell proliferation and mass remained unaffected. Moreover, ablation of blood vessels did not prevent \u03b2-cell generation after severe pancreas injury by partial pancreatic duct ligation or partial pancreatectomy. Our data thus argue against a major role of blood vessels to preserve adult \u03b2-cell generation and function, restricting their importance to facilitating rapid and adequate insulin delivery.<\/jats:p>","DOI":"10.2337\/db12-1827","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T05:01:06Z","timestamp":1377320466000},"page":"4165-4173","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":23,"title":["Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult \u03b2-Cell Mass or Function"],"prefix":"10.2337","volume":"62","author":[{"given":"Joke","family":"D'Hoker","sequence":"first","affiliation":[{"name":"Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"De Leu","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Vrije Universiteit 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