{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:04:54Z","timestamp":1781661894789,"version":"3.54.5"},"reference-count":46,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":2752,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:p>Gastric bypass surgery can dramatically improve type 2 diabetes. It has been hypothesized that by excluding duodenum and jejunum from nutrient transit, this procedure may reduce putative signals from the proximal intestine that negatively influence insulin sensitivity (SI). To test this hypothesis, resection or bypass of different intestinal segments were performed in diabetic Goto-Kakizaki and Wistar rats. Rats were randomly assigned to five groups: duodenal-jejunal bypass (DJB), jejunal resection (jejunectomy), ileal resection (ileectomy), pair-fed sham-operated, and nonoperated controls. Oral glucose tolerance test was performed within 2 weeks after surgery. Baseline and poststimulation levels of glucose, insulin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were measured. Minimal model analysis was used to assess SI. SI improved after DJB (SI = 1.14 \u00b1 0.32 \u00d7 10\u22124 min\u22121 \u22c5 pM\u22121) and jejunectomy (SI = 0.80 \u00b1 0.14 \u00d7 10\u22124 min\u22121 \u22c5 pM\u22121), but not after ileectomy or sham operation\/pair feeding in diabetic rats. Both DJB and jejunal resection normalized SI in diabetic rats as shown by SI levels equivalent to those of Wistar rats (SI = 1.01 \u00b1 0.06 \u00d7 10\u22124 min\u22121 \u22c5 pM\u22121; P = NS). Glucose effectiveness did not change after operations in any group. While ileectomy increased plasma GIP levels, no changes in GIP or GLP-1 were observed after DJB and jejunectomy. These findings support the hypothesis that anatomic alterations of the proximal small bowel may reduce factors associated with negative influence on SI, therefore contributing to the control of diabetes after gastric bypass surgery.<\/jats:p>","DOI":"10.2337\/db13-0856","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T06:28:56Z","timestamp":1384583336000},"page":"1069-1078","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":51,"title":["Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion"],"prefix":"10.2337","volume":"63","author":[{"given":"Serenella","family":"Salinari","sequence":"first","affiliation":[{"name":"Department of Computer, Control, and Management Engineering \u201cAntonio Ruberti,\u201d University of Rome \u201cSapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel W.","family":"le Roux","sequence":"additional","affiliation":[{"name":"Diabetes Complications Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bertuzzi","sequence":"additional","affiliation":[{"name":"Institute of Systems Analysis and Computer Science, National Research Council, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rubino","sequence":"additional","affiliation":[{"name":"Bariatric and Metabolic Surgery, King\u2019s College London, London, United Kingdom"},{"name":"Department of Surgery, Catholic University, School of Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geltrude","family":"Mingrone","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"2022031211045148600_B1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00000658-198709000-00009","article-title":"The control of diabetes mellitus (NIDDM) in the morbidly obese with the Greenville Gastric Bypass","volume":"206","author":"Pories","year":"1987","journal-title":"Ann Surg"},{"key":"2022031211045148600_B2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000658-199509000-00011","article-title":"Who would have thought it? 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