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High-fat diet enhanced glucose intolerance, brain soluble A\u03b2, and memory impairment in 3xTg-AD mice. Strikingly, a single insulin injection reversed the deleterious effects of HFD on memory and soluble A\u03b2 levels, partly through changes in A\u03b2 production and\/or clearance. Our results are consistent with the development of a vicious cycle between AD and diabetes, potentiating both peripheral metabolic disorders and AD neuropathology. The capacity of insulin to rapidly break the deleterious effects of this cycle on soluble A\u03b2 concentrations and memory has important therapeutic implications.<\/jats:p>","DOI":"10.2337\/db14-0375","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T03:04:07Z","timestamp":1404961447000},"page":"4291-4301","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":226,"title":["Insulin Reverses the High-Fat Diet\u2013Induced Increase in Brain A\u03b2 and Improves Memory in an Animal Model of Alzheimer Disease"],"prefix":"10.2337","volume":"63","author":[{"given":"Milene","family":"Vandal","sequence":"first","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Axe Neurosciences, Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Institut des Nutraceutiques et des Aliments Fonctionnels, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"White","sequence":"additional","affiliation":[{"name":"Institut des Nutraceutiques et des Aliments Fonctionnels, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Sarah W. 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