{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:42:48Z","timestamp":1791423768537,"version":"4.3.3"},"reference-count":24,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":342,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["VR K2011-65X-12219-15-6"],"award-info":[{"award-number":["VR K2011-65X-12219-15-6"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["Olle Korsgren"],"award-info":[{"award-number":["Olle Korsgren"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["Knut Dahl-J\u00f8rgensen"],"award-info":[{"award-number":["Knut Dahl-J\u00f8rgensen"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Foundation International","doi-asserted-by":"crossref","award":["Olle Korsgren"],"award-info":[{"award-number":["Olle Korsgren"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000273","name":"Diabetes Wellness foundation","doi-asserted-by":"crossref","award":["Olle Korsgren"],"award-info":[{"award-number":["Olle Korsgren"]}],"id":[{"id":"10.13039\/501100000273","id-type":"DOI","asserted-by":"crossref"}]},{"name":"PEVNET Study Group","award":["European Union\u2019s Seventh Framework Programme (FP7\/2007-2013)"],"award-info":[{"award-number":["European Union\u2019s Seventh Framework Programme (FP7\/2007-2013)"]}]},{"name":"The Novo Nordisk Foundation","award":["Knut Dahl-J\u00f8rgensen"],"award-info":[{"award-number":["Knut Dahl-J\u00f8rgensen"]}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["255770"],"award-info":[{"award-number":["255770"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["132362"],"award-info":[{"award-number":["132362"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:p>The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3\u20139 weeks after onset of type 1 diabetes in six adult patients (age 24\u201335 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen whole pancreatic tissue using PCR and sequencing. Nondiabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetic patients (two of nine controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (one of nine controls). Enterovirus-specific RNA sequences were detected in four of six patients (zero of six controls). The results were confirmed in various laboratories. Only 1.7% of the islets contained VP1+ cells, and the amount of enterovirus RNA was low. The results provide evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, which is consistent with the possibility that a low-grade enteroviral infection in the pancreatic islets contributes to disease progression in humans.<\/jats:p>","DOI":"10.2337\/db14-1370","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:02:01Z","timestamp":1416873721000},"page":"1682-1687","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":304,"title":["Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes"],"prefix":"10.2337","volume":"64","author":[{"given":"Lars","family":"Krogvold","sequence":"first","affiliation":[{"name":"Paediatric Department, Oslo University Hospital, Oslo, 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