{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:26:21Z","timestamp":1791300381124,"version":"4.1.0"},"reference-count":33,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":298,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","award":["U982"],"award-info":[{"award-number":["U982"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003191","name":"Conseil R\u00e9gional de Haute-Normandie","doi-asserted-by":"crossref","award":["U982"],"award-info":[{"award-number":["U982"]}],"id":[{"id":"10.13039\/501100003191","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Plateforme R\u00e9gionale de Recherche en Imagerie Cellulaire de Haute-Normandie","award":["U982"],"award-info":[{"award-number":["U982"]}]},{"name":"Institute for Research and Innovation in Biomedecine","award":["U982"],"award-info":[{"award-number":["U982"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:p>26RFa is a hypothalamic neuropeptide that promotes food intake. 26RFa is upregulated in obese animal models, and its orexigenic activity is accentuated in rodents fed a high-fat diet, suggesting that this neuropeptide might play a role in the development and maintenance of the obese status. As obesity is frequently associated with type 2 diabetes, we investigated whether 26RFa may be involved in the regulation of glucose homeostasis. In the current study, we show a moderate positive correlation between plasma 26RFa levels and plasma insulin in patients with diabetes. Plasma 26RFa concentration also increases in response to an oral glucose tolerance test. In addition, we found that 26RFa and its receptor GPR103 are present in human pancreatic \u03b2-cells as well as in the gut. In mice, 26RFa attenuates the hyperglycemia induced by a glucose load, potentiates insulin sensitivity, and increases plasma insulin concentrations. Consistent with these data, 26RFa stimulates insulin production by MIN6 insulinoma cells. Finally, we show, using in vivo and in vitro approaches, that a glucose load induces a massive secretion of 26RFa by the small intestine. Altogether, the present data indicate that 26RFa acts as an incretin to regulate glucose homeostasis.<\/jats:p>","DOI":"10.2337\/db14-1864","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T02:31:34Z","timestamp":1428633094000},"page":"2805-2816","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":40,"title":["Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis"],"prefix":"10.2337","volume":"64","author":[{"given":"Ga\u00ebtan","family":"Pr\u00e9vost","sequence":"first","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Institute for Research and Innovation in Biomedicine, University Hospital of Rouen, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Jeandel","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Arabo","sequence":"additional","affiliation":[{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo\u00efse","family":"Co\u00ebffier","sequence":"additional","affiliation":[{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"},{"name":"INSERM U1073, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Department of Nutrition, University Hospital of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariama","family":"El Ouahli","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"},{"name":"Biological Engineering Laboratory, Life Sciences, Sultan Moulay Slimane University, Beni-Mellal, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Picot","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alexandre","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Gobet","sequence":"additional","affiliation":[{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"},{"name":"Department of Pathology, University Hospital of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Leprince","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind","family":"Berrahmoune","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Institute for Research and Innovation in Biomedicine, University Hospital of Rouen, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"D\u00e9chelotte","sequence":"additional","affiliation":[{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"},{"name":"INSERM U1073, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Department of Nutrition, University Hospital of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Malagon","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology, and Immunology, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba\/Reina Sof\u00eda University Hospital, University of Cordoba, Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bonner","sequence":"additional","affiliation":[{"name":"INSERM U859, Biotherapies of Diabetes, Faculty of Medicine, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kerr-Conte","sequence":"additional","affiliation":[{"name":"INSERM U859, Biotherapies of Diabetes, Faculty of Medicine, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Chigr","sequence":"additional","affiliation":[{"name":"Biological Engineering Laboratory, Life Sciences, Sultan Moulay Slimane University, Beni-Mellal, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Institute for Research and Innovation in Biomedicine, University Hospital of Rouen, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Anouar","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Chartrel","sequence":"additional","affiliation":[{"name":"INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France"},{"name":"Normandy University, Caen, France"},{"name":"University of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"2022031300370665500_B1","doi-asserted-by":"crossref","first-page":"15247","DOI":"10.1073\/pnas.2434676100","article-title":"Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity","volume":"100","author":"Chartrel","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031300370665500_B2","doi-asserted-by":"crossref","first-page":"46387","DOI":"10.1074\/jbc.M305270200","article-title":"A new peptidic ligand and its receptor regulating adrenal function in rats","volume":"278","author":"Fukusumi","year":"2003","journal-title":"J Biol Chem"},{"key":"2022031300370665500_B3","doi-asserted-by":"crossref","first-page":"27652","DOI":"10.1074\/jbc.M302945200","article-title":"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155","volume":"278","author":"Jiang","year":"2003","journal-title":"J Biol Chem"},{"key":"2022031300370665500_B4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1471-4159.2006.04090.x","article-title":"Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord","volume":"99","author":"Bruzzone","year":"2006","journal-title":"J Neurochem"},{"key":"2022031300370665500_B5","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.0602371103","article-title":"A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice","volume":"103","author":"Takayasu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031300370665500_B6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.yfrne.2011.04.001","article-title":"The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions","volume":"32","author":"Chartrel","year":"2011","journal-title":"Front Neuroendocrinol"},{"key":"2022031300370665500_B7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/cne.21400","article-title":"Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat","volume":"503","author":"Bruzzone","year":"2007","journal-title":"J Comp Neurol"},{"key":"2022031300370665500_B8","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1210\/en.2005-1580","article-title":"RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice","volume":"147","author":"Moriya","year":"2006","journal-title":"Endocrinology"},{"key":"2022031300370665500_B9","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1210\/en.2008-1432","article-title":"The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleus","volume":"150","author":"Lectez","year":"2009","journal-title":"Endocrinology"},{"key":"2022031300370665500_B10","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.peptides.2008.07.024","article-title":"Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats","volume":"29","author":"Primeaux","year":"2008","journal-title":"Peptides"},{"key":"2022031300370665500_B11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-002-1009-0","article-title":"The relative contributions of insulin resistance and \u03b2-cell dysfunction to the pathophysiology of Type 2 diabetes","volume":"46","author":"Kahn","year":"2003","journal-title":"Diabetologia"},{"key":"2022031300370665500_B12","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1172\/JCI29103","article-title":"Islet \u03b2 cell failure in type 2 diabetes","volume":"116","author":"Prentki","year":"2006","journal-title":"J Clin Invest"},{"key":"2022031300370665500_B13","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.metabol.2014.05.012","article-title":"\u03b2-Cell function in type 2 diabetes","volume":"63","author":"Ferrannini","year":"2014","journal-title":"Metabolism"},{"key":"2022031300370665500_B14","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1210\/en.2007-0404","article-title":"Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice","volume":"148","author":"Imai","year":"2007","journal-title":"Endocrinology"},{"key":"2022031300370665500_B15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2337\/diabetes.52.1.111","article-title":"Glucose regulates the release of orexin-a from the endocrine pancreas","volume":"52","author":"Ouedraogo","year":"2003","journal-title":"Diabetes"},{"key":"2022031300370665500_B16","first-page":"3183","article-title":"Ghrelin\u2019s second life: from appetite stimulator to glucose regulator","volume":"18","author":"Verhulst","year":"2012","journal-title":"World J Gastroenterol"},{"key":"2022031300370665500_B17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1073\/pnas.0913610107","article-title":"CRFR1 is expressed on pancreatic \u03b2 cells, promotes \u03b2 cell proliferation, and potentiates insulin secretion in a glucose-dependent manner","volume":"107","author":"Huising","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031300370665500_B18","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1152\/ajpendo.00385.2009","article-title":"Apelin is necessary for the maintenance of insulin sensitivity","volume":"298","author":"Yue","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022031300370665500_B19","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1210\/en.2006-0143","article-title":"Minireview: the brain as a molecular target for diabetic therapy","volume":"147","author":"Prodi","year":"2006","journal-title":"Endocrinology"},{"key":"2022031300370665500_B20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature12709","article-title":"Cooperation between brain and islet in glucose homeostasis and diabetes","volume":"503","author":"Schwartz","year":"2013","journal-title":"Nature"},{"key":"2022031300370665500_B21","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1210\/jc.2011-3396","article-title":"Orexigenic neuropeptide 26RFa: new evidence for an adaptive profile of appetite regulation in anorexia nervosa","volume":"97","author":"Galusca","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300370665500_B22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"2022031300370665500_B23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/nmo.12150","article-title":"Glucose-induced incretin hormone release and insulin sensitivity are impaired in patients with idiopathic gastroparesis: results from a pilot descriptive study","volume":"25","author":"Pr\u00e9vost","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"2022031300370665500_B24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejca.2012.05.028","article-title":"The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells","volume":"49","author":"Alonzeau","year":"2013","journal-title":"Eur J Cancer"},{"key":"2022031300370665500_B25","first-page":"2944","article-title":"Identification of a novel secretogranin II-derived peptide (SgII(187-252)) in adult and fetal human adrenal glands using antibodies raised against the human recombinant peptide","volume":"83","author":"Anouar","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300370665500_B26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1210\/endo-127-1-126","article-title":"Establishment of a pancreatic \u03b2 cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms","volume":"127","author":"Miyazaki","year":"1990","journal-title":"Endocrinology"},{"key":"2022031300370665500_B27","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1210\/en.2013-1167","article-title":"The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human \u03b2-cells and its targeted inactivation impairs glucose tolerance","volume":"154","author":"Pr\u00e9vost","year":"2013","journal-title":"Endocrinology"},{"key":"2022031300370665500_B28"},{"key":"2022031300370665500_B29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.2040-1124.2010.00022.x","article-title":"GIP and GLP-1, the two incretin hormones: Similarities and differences","volume":"1","author":"Seino","year":"2010","journal-title":"J Diabetes Investig"},{"key":"2022031300370665500_B30","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.2337\/db13-1522","article-title":"RFamide peptides 43RFa and 26RFa both promote survival of pancreatic \u03b2-cells and human pancreatic islets but exert opposite effects on insulin secretion","volume":"63","author":"Granata","year":"2014","journal-title":"Diabetes"},{"key":"2022031300370665500_B31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.peptides.2006.04.004","article-title":"26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas","volume":"28","author":"Egido","year":"2007","journal-title":"Peptides"},{"key":"2022031300370665500_B32","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1210\/me.2010-0010","article-title":"GPR103b functions in the peripheral regulation of adipogenesis","volume":"24","author":"Mulumba","year":"2010","journal-title":"Mol Endocrinol"},{"key":"2022031300370665500_B33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metab"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/64\/8\/2805\/581379\/db141864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/64\/8\/2805\/581379\/db141864.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:45:12Z","timestamp":1667407512000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/64\/8\/2805\/34791\/Hypothalamic-Neuropeptide-26RFa-Acts-as-an"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,4,9]]},"published-print":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db14-1864","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}