{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:55:16Z","timestamp":1769010916554,"version":"3.49.0"},"reference-count":20,"publisher":"American Diabetes Association","issue":"5","funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["K2013\u201354X-09894\u201319-3"],"award-info":[{"award-number":["K2013\u201354X-09894\u201319-3"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Commission FP7","award":["245009, Full4Health FP7-KBBE-2010\u20134- 266408"],"award-info":[{"award-number":["245009, Full4Health FP7-KBBE-2010\u20134- 266408"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"DOI":"10.2337\/db14-1910","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T19:26:48Z","timestamp":1429817208000},"page":"1498-1499","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["Brain IL-6\u2014Where Amylin and GLP-1 Antiobesity Signaling Congregate"],"prefix":"10.2337","volume":"64","author":[{"given":"John-Olov","family":"Jansson","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilborg","family":"Palsdottir","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"2022031303271120600_B1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"2022031303271120600_B2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2012.06.015","article-title":"Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance","volume":"16","author":"Grill","year":"2012","journal-title":"Cell Metab"},{"key":"2022031303271120600_B3","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/db14-0645","article-title":"Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling","volume":"64","author":"Le Foll","year":"2015","journal-title":"Diabetes"},{"key":"2022031303271120600_B4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-nutr-071812-161201","article-title":"Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose","volume":"34","author":"Hayes","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"2022031303271120600_B5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1463-1326.2012.01670.x","article-title":"The interaction of amylin with other hormones in the control of eating","volume":"15","author":"Lutz","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"2022031303271120600_B6","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031303271120600_B7","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1517\/14656566.2011.581663","article-title":"Pramlintide and the treatment of diabetes: a review of the data since its introduction","volume":"12","author":"Younk","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"2022031303271120600_B8","doi-asserted-by":"crossref","first-page":"16199","DOI":"10.1073\/pnas.1306799110","article-title":"Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6","volume":"110","author":"Shirazi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031303271120600_B9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tem.2013.01.004","article-title":"Is there a place for incretin therapies in obesity and prediabetes","volume":"24","author":"Holst","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"2022031303271120600_B10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.coph.2013.08.013","article-title":"Molecular mechanisms of incretin hormone secretion","volume":"13","author":"Ezcurra","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"2022031303271120600_B11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.7150\/ijbs.4828","article-title":"The pathological and physiological roles of IL-6 amplifier activation","volume":"8","author":"Murakami","year":"2012","journal-title":"Int J Biol Sci"},{"key":"2022031303271120600_B12","first-page":"329","article-title":"Expression of interleukin-6 in tumor-bearing mice with cytokine dependent cachexia","volume":"5","author":"Lonnroth","year":"1994","journal-title":"Int J Oncol"},{"key":"2022031303271120600_B13","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00125-010-1865-y","article-title":"Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance","volume":"53","author":"Matthews","year":"2010","journal-title":"Diabetologia"},{"key":"2022031303271120600_B14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm0102-75","article-title":"Interleukin-6-deficient mice develop mature-onset obesity","volume":"8","author":"Wallenius","year":"2002","journal-title":"Nat Med"},{"key":"2022031303271120600_B15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbi.2009.09.002","article-title":"Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat","volume":"24","author":"Hidalgo","year":"2010","journal-title":"Brain Behav Immun"},{"key":"2022031303271120600_B16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00125-009-1580-8","article-title":"Human IL6 enhances leptin action in mice","volume":"53","author":"Sadagurski","year":"2010","journal-title":"Diabetologia"},{"key":"2022031303271120600_B17","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0006-291X(02)00230-9","article-title":"Intracerebroventricular interleukin-6 treatment decreases body fat in rats","volume":"293","author":"Wallenius","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2022031303271120600_B18","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.2337\/db05-1622","article-title":"Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats","volume":"55","author":"Flores","year":"2006","journal-title":"Diabetes"},{"key":"2022031303271120600_B19","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1210\/en.2014-1248","article-title":"GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence","volume":"155","author":"Richard","year":"2014","journal-title":"Endocrinology"},{"key":"2022031303271120600_B20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nm.2513","article-title":"Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells","volume":"17","author":"Ellingsgaard","year":"2011","journal-title":"Nat Med"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/64\/5\/1498\/580011\/db141910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/64\/5\/1498\/580011\/db141910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:45:19Z","timestamp":1667407519000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/64\/5\/1498\/40521\/Brain-IL-6-Where-Amylin-and-GLP-1-Antiobesity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,4,16]]},"published-print":{"date-parts":[[2015,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db14-1910","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]}}}