{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:48:26Z","timestamp":1790927306100,"version":"4.1.0"},"reference-count":79,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2009-4120"],"award-info":[{"award-number":["2009-4120"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2010-2932"],"award-info":[{"award-number":["2010-2932"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2011-3900"],"award-info":[{"award-number":["2011-3900"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2014-3352"],"award-info":[{"award-number":["2014-3352"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lund University Diabetes Centre"},{"name":"Regional Research Funds"},{"name":"Vascular Wall Programme"},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvall Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Marianne & Marcus Wallenberg Foundation"},{"DOI":"10.13039\/100018049","name":"Hulda Almroth Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006686","name":"Segerfalk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006686","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Malm\u00f6 and Sk\u00e5ne Hospital Research Funds"},{"DOI":"10.13039\/501100005753","name":"Royal Physiographic Society in Lund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Knut & Alice Wallenberg Foundation","award":["KAW 2009-0243"],"award-info":[{"award-number":["KAW 2009-0243"]}]},{"name":"\u212bke Wiberg Foundation"},{"name":"Lars Hierta Memorial"},{"name":"The Swedish Diabetes Association"},{"DOI":"10.13039\/501100006189","name":"Albert P\u00e5hlsson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006189","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lundgren Foundation"},{"DOI":"10.13039\/501100009748","name":"Ernhold Lundstr\u00f6m Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009748","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Thelma Zo\u00e9ga Foundation"},{"name":"European Research Council Advanced Research Grant","award":["GA269045"],"award-info":[{"award-number":["GA269045"]}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU7th Framework programme","award":["HEALTH 2007-201413 (ENGAGE)"],"award-info":[{"award-number":["HEALTH 2007-201413 (ENGAGE)"]}]},{"name":"EU7th Framework programme","award":["HEALTH-F2-2009-241544 (PREDICTIONS)"],"award-info":[{"award-number":["HEALTH-F2-2009-241544 (PREDICTIONS)"]}]},{"name":"EU7th Framework programme","award":["QLG2-CT-2001-01669 (EURAGEDIC)"],"award-info":[{"award-number":["QLG2-CT-2001-01669 (EURAGEDIC)"]}]},{"DOI":"10.13039\/501100007687","name":"Swedish Medical Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["HLF20080843"],"award-info":[{"award-number":["HLF20080843"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["HLF20090419"],"award-info":[{"award-number":["HLF20090419"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["HLF20090704"],"award-info":[{"award-number":["HLF20090704"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["HLF20100532"],"award-info":[{"award-number":["HLF20100532"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["HLF20130700"],"award-info":[{"award-number":["HLF20130700"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of endothelin-1 and activation of CREB. Infusion of GIP increases plasma OPN concentrations in healthy individuals. Plasma endothelin-1 and OPN concentrations are positively correlated in patients with critical limb ischemia. Fasting GIP concentrations are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared with control subjects. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients, and expression associates with parameters that are characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration, and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from humans, mice, rats, and pigs, remarkable upregulation is observed in endothelial and smooth muscle cells upon culture conditions, yielding a \u201cvascular disease\u2013like\u201d phenotype. Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.<\/jats:p>","DOI":"10.2337\/db15-0122","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T03:38:16Z","timestamp":1442979496000},"page":"239-254","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":62,"title":["Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB"],"prefix":"10.2337","volume":"65","author":[{"given":"Lisa M.","family":"Berglund","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya","family":"Lyssenko","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"},{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Ladenvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kotova","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Edsfeldt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Pilgaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Alkayyali","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Br\u00f8ns","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Forsblom","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics, Folkh\u00e4lsan Research Center, Biomedicum Helsinki, Helsinki, Finland"},{"name":"Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Zetterqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Nitulescu","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Ruiz","family":"McDavitt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Dun\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Stanc\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kuusisto","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ahlqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lajer","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"},{"name":"HEALTH University of Aarhus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Madsbad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"},{"name":"HEALTH University of Aarhus, Aarhus, Denmark"},{"name":"NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences and Surgery, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marju","family":"Orho-Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Henrik","family":"Groop","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics, Folkh\u00e4lsan Research Center, Biomedicum Helsinki, Helsinki, Finland"},{"name":"Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"},{"name":"Steno Diabetes Center A\/S, Gentofte, Denmark"},{"name":"Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Gotts\u00e4ter","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Laakso","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Groop","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"2022031300454266600_B1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-381517-0.00002-3","article-title":"Pleiotropic actions of the incretin hormones","volume":"84","author":"McIntosh","year":"2010","journal-title":"Vitam Horm"},{"key":"2022031300454266600_B2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.clinthera.2011.04.024","article-title":"Clinical pharmacology of incretin therapies for type 2 diabetes mellitus: implications for treatment","volume":"33","author":"Neumiller","year":"2011","journal-title":"Clin Ther"},{"key":"2022031300454266600_B3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/er.2011-1052","article-title":"Cardiovascular biology of the incretin system","volume":"33","author":"Ussher","year":"2012","journal-title":"Endocr Rev"},{"key":"2022031300454266600_B4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3181\/00379727-158-40222","article-title":"Gastric inhibitory polypeptide increases mesenteric blood flow","volume":"158","author":"Fara","year":"1978","journal-title":"Proc Soc Exp Biol Med"},{"key":"2022031300454266600_B5","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1007\/BF01299856","article-title":"Effects of gastric inhibitory polypeptide and glucagon on portal venous and hepatic arterial flow in conscious dogs","volume":"37","author":"Kogire","year":"1992","journal-title":"Dig Dis Sci"},{"key":"2022031300454266600_B6","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0196-9781(00)00287-4","article-title":"Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells","volume":"21","author":"Zhong","year":"2000","journal-title":"Peptides"},{"key":"2022031300454266600_B7","doi-asserted-by":"crossref","first-page":"E773","DOI":"10.1152\/ajpendo.00507.2003","article-title":"Glucose-dependent insulinotropic peptide: differential effects on hepatic artery vs. portal vein endothelial cells","volume":"286","author":"Ding","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022031300454266600_B8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.atherosclerosis.2008.03.006","article-title":"Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis","volume":"199","author":"Ivey","year":"2008","journal-title":"Atherosclerosis"},{"key":"2022031300454266600_B9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/15604280214939","article-title":"Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complications","volume":"3","author":"Chakrabarti","year":"2002","journal-title":"Int J Exp Diabetes Res"},{"key":"2022031300454266600_B10","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1172\/JCI116755","article-title":"Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques","volume":"92","author":"Giachelli","year":"1993","journal-title":"J Clin Invest"},{"key":"2022031300454266600_B11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2334\/josnusd.52.221","article-title":"Endothelin-1 regulates rat bone sialoprotein gene transcription","volume":"52","author":"Li","year":"2010","journal-title":"J Oral Sci"},{"key":"2022031300454266600_B12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","article-title":"The role of osteopontin in inflammatory processes","volume":"3","author":"Lund","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"2022031300454266600_B13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s003800200005","article-title":"Development of atherosclerosis in osteopontin transgenic mice","volume":"16","author":"Chiba","year":"2002","journal-title":"Heart Vessels"},{"key":"2022031300454266600_B14","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI200318141","article-title":"Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice","volume":"112","author":"Bruemmer","year":"2003","journal-title":"J Clin Invest"},{"key":"2022031300454266600_B15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0021-9150(03)00298-3","article-title":"Plasma osteopontin levels are associated with the presence and extent of coronary artery disease","volume":"170","author":"Ohmori","year":"2003","journal-title":"Atherosclerosis"},{"key":"2022031300454266600_B16","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.ATV.0000194157.26665.e6","article-title":"High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention","volume":"26","author":"Kato","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022031300454266600_B17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/ATVBAHA.109.199299","article-title":"Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia","volume":"30","author":"Nilsson-Berglund","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022031300454266600_B18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/01.ATV.20.3.624","article-title":"Enhanced expression of osteopontin in human diabetic artery and analysis of its functional role in accelerated atherogenesis","volume":"20","author":"Takemoto","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022031300454266600_B19","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.2337\/db10-1532","article-title":"Pleiotropic effects of GIP on islet function involve osteopontin","volume":"60","author":"Lyssenko","year":"2011","journal-title":"Diabetes"},{"key":"2022031300454266600_B20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bbrc.2012.07.157","article-title":"Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B","volume":"425","author":"Omar","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"2022031300454266600_B21","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.2337\/db12-0976","article-title":"Link between GIP and osteopontin in adipose tissue and insulin resistance","volume":"62","author":"Ahlqvist","year":"2013","journal-title":"Diabetes"},{"key":"2022031300454266600_B22","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/mnfr.200700048","article-title":"Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome","volume":"51","author":"Nitz","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"2022031300454266600_B23","doi-asserted-by":"crossref","first-page":"C1167","DOI":"10.1152\/ajpcell.00590.2005","article-title":"Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation","volume":"292","author":"Nilsson","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"2022031300454266600_B24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000109415.17511.18","article-title":"Calcineurin\/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy","volume":"94","author":"Wilkins","year":"2004","journal-title":"Circ Res"},{"key":"2022031300454266600_B25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1074-7613(00)80612-3","article-title":"The transcription factor NFAT4 is involved in the generation and survival of T cells","volume":"9","author":"Oukka","year":"1998","journal-title":"Immunity"},{"key":"2022031300454266600_B26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jvs.2005.03.025","article-title":"Inflammatory mediators are associated with 1-year mortality in critical limb ischemia","volume":"42","author":"Barani","year":"2005","journal-title":"J Vasc Surg"},{"key":"2022031300454266600_B27","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/01.STR.0000058157.69113.F6","article-title":"Changes related to age and cerebrovascular symptoms in the extracellular matrix of human carotid plaques","volume":"34","author":"Gon\u00e7alves","year":"2003","journal-title":"Stroke"},{"key":"2022031300454266600_B28","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1210\/jc.2005-0382","article-title":"Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight","volume":"90","author":"Schou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300454266600_B29","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/cvr\/cvr309","article-title":"NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis","volume":"93","author":"Berglund","year":"2012","journal-title":"Cardiovasc Res"},{"key":"2022031300454266600_B30","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00125-010-1776-y","article-title":"A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study","volume":"53","author":"Isomaa","year":"2010","journal-title":"Diabetologia"},{"key":"2022031300454266600_B31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2796.1993.tb00647.x","article-title":"The Malmo Diet and Cancer Study. Design and feasibility","volume":"233","author":"Berglund","year":"1993","journal-title":"J Intern Med"},{"key":"2022031300454266600_B32","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2337\/db08-1607","article-title":"Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men","volume":"58","author":"Stanc\u00e1kov\u00e1","year":"2009","journal-title":"Diabetes"},{"key":"2022031300454266600_B33","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1023\/A:1020036805655","article-title":"Classifying diabetes according to the new WHO clinical stages","volume":"17","author":"Lindholm","year":"2001","journal-title":"Eur J Epidemiol"},{"key":"2022031300454266600_B34","doi-asserted-by":"crossref","first-page":"e13421","DOI":"10.1371\/journal.pone.0013421","article-title":"Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy","volume":"5","author":"Alkhalaf","year":"2010","journal-title":"PLoS One"},{"key":"2022031300454266600_B35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ndt\/gfm501","article-title":"European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy","volume":"23","author":"Tarnow","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"2022031300454266600_B36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-2796.2000.00568.x","article-title":"Long-term outcome of the Malm\u00f6 Preventive Project: mortality and cardiovascular morbidity","volume":"247","author":"Berglund","year":"2000","journal-title":"J Intern Med"},{"key":"2022031300454266600_B37","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s00125-003-1194-5","article-title":"Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients","volume":"46","author":"Saraheimo","year":"2003","journal-title":"Diabetologia"},{"key":"2022031300454266600_B38","doi-asserted-by":"crossref","first-page":"E390","DOI":"10.1152\/ajpendo.00509.2002","article-title":"Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1","volume":"285","author":"Ding","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022031300454266600_B39","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1194\/jlr.M006841","article-title":"GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene","volume":"51","author":"Kim","year":"2010","journal-title":"J Lipid Res"},{"key":"2022031300454266600_B40","doi-asserted-by":"crossref","first-page":"43062","DOI":"10.1074\/jbc.M111.289009","article-title":"Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110\u03b2 isoform of phosphatidylinositol 3-kinase","volume":"286","author":"Mohammad","year":"2011","journal-title":"J Biol Chem"},{"key":"2022031300454266600_B41","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/01.RES.0000078491.79697.7F","article-title":"Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression","volume":"92","author":"Rodr\u00edguez-Pascual","year":"2003","journal-title":"Circ Res"},{"key":"2022031300454266600_B42","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cardiores.2007.05.019","article-title":"Autocrine expression of osteopontin contributes to PDGF-mediated arterial smooth muscle cell migration","volume":"75","author":"Jalvy","year":"2007","journal-title":"Cardiovasc Res"},{"key":"2022031300454266600_B43","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.RES.0000266609.28312.de","article-title":"CREB mediates UTP-directed arterial smooth muscle cell migration and expression of the chemotactic protein osteopontin via its interaction with activator protein-1 sites","volume":"100","author":"Jalvy","year":"2007","journal-title":"Circ Res"},{"key":"2022031300454266600_B44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1527-3466.2006.00261.x","article-title":"The many faces of H89: a review","volume":"24","author":"Lochner","year":"2006","journal-title":"Cardiovasc Drug Rev"},{"key":"2022031300454266600_B45","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1210\/jc.2002-021873","article-title":"Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus","volume":"88","author":"Vilsb\u00f8ll","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300454266600_B46","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"Owens","year":"2004","journal-title":"Physiol Rev"},{"key":"2022031300454266600_B47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-201X.1998.tb10707.x","article-title":"Long-term effects of intracellular calcium and growth factors on excitation and contraction in smooth muscle","volume":"164","author":"Hellstrand","year":"1998","journal-title":"Acta Physiol Scand"},{"key":"2022031300454266600_B48","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00424-008-0491-8","article-title":"The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease","volume":"456","author":"House","year":"2008","journal-title":"Pflugers Arch"},{"key":"2022031300454266600_B49","first-page":"571","article-title":"The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid","volume-title":"Biochim Biophys Acta","author":"Guo","year":"2008"},{"key":"2022031300454266600_B50","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yexmp.2009.10.006","article-title":"Disruption of actin cytoskeleton mediates loss of tensile stress induced early phenotypic modulation of vascular smooth muscle cells in organ culture","volume":"88","author":"Zheng","year":"2010","journal-title":"Exp Mol Pathol"},{"key":"2022031300454266600_B51","first-page":"125","article-title":"Osteopontin in cardiovascular disease: a potential therapeutic target","volume-title":"Cardiol Rev","author":"Waller","year":"2010"},{"key":"2022031300454266600_B52","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1172\/JCI116901","article-title":"Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta","volume":"92","author":"Ikeda","year":"1993","journal-title":"J Clin Invest"},{"key":"2022031300454266600_B53","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/ATVBAHA.109.194944","article-title":"Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events","volume":"30","author":"de Kleijn","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022031300454266600_B54","first-page":"3575","article-title":"Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide","volume":"85","author":"Deacon","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300454266600_B55","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1210\/jc.2006-1009","article-title":"Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes","volume":"91","author":"Herman","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031300454266600_B56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tips.2004.02.008","article-title":"Historical review: endothelin","volume":"25","author":"Masaki","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"2022031300454266600_B57","doi-asserted-by":"crossref","first-page":"350","DOI":"10.5144\/0256-4947.1993.350","article-title":"Gastric inhibitory polypeptide (GIP) responses in type 2 diabetes using three different antibodies","volume":"13","author":"Alam","year":"1993","journal-title":"Ann Saudi Med"},{"key":"2022031300454266600_B58","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.2337\/dc13-0465","article-title":"Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies","volume":"36","author":"Calanna","year":"2013","journal-title":"Diabetes Care"},{"key":"2022031300454266600_B59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2840-9-17","article-title":"Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease","volume":"9","author":"Yamaoka-Tojo","year":"2010","journal-title":"Cardiovasc Diabetol"},{"key":"2022031300454266600_B60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.atherosclerosis.2014.08.042","article-title":"Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients","volume":"237","author":"Grufman","year":"2014","journal-title":"Atherosclerosis"},{"key":"2022031300454266600_B61","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/01.STR.0000129790.00318.a3","article-title":"Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosis","volume":"35","author":"Golledge","year":"2004","journal-title":"Stroke"},{"key":"2022031300454266600_B62","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1076\/ceyr.25.6.381.14238","article-title":"Upregulation of glucose-dependent insulinotropic polypeptide and its receptor in the retina of streptozotocin-induced diabetic rats","volume":"25","author":"Cho","year":"2002","journal-title":"Curr Eye Res"},{"key":"2022031300454266600_B63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1096\/fj.02-0243fje","article-title":"A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells","volume":"17","author":"Lynn","year":"2003","journal-title":"FASEB J"},{"key":"2022031300454266600_B64","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2337\/db06-1033","article-title":"Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes","volume":"56","author":"Xu","year":"2007","journal-title":"Diabetes"},{"key":"2022031300454266600_B65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2337\/db09-1899","article-title":"Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired \u03b2-cell function?","volume":"59","author":"Meier","year":"2010","journal-title":"Diabetes"},{"key":"2022031300454266600_B66","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1128\/MCB.00256-14","article-title":"A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity","volume":"34","author":"Mohammad","year":"2014","journal-title":"Mol Cell Biol"},{"key":"2022031300454266600_B67","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease","volume":"43","author":"Schunkert","year":"2011","journal-title":"Nat Genet"},{"key":"2022031300454266600_B68","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s00125-011-2241-2","article-title":"Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice","volume":"54","author":"Nagashima","year":"2011","journal-title":"Diabetologia"},{"key":"2022031300454266600_B69","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.metabol.2011.11.011","article-title":"Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice","volume":"61","author":"Terasaki","year":"2012","journal-title":"Metabolism"},{"key":"2022031300454266600_B70","doi-asserted-by":"crossref","first-page":"e35683","DOI":"10.1371\/journal.pone.0035683","article-title":"Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice","volume":"7","author":"Nogi","year":"2012","journal-title":"PLoS One"},{"key":"2022031300454266600_B71","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1365-2362.2003.01181.x","article-title":"Fatty acids modulate the effect of darglitazone on macrophage CD36 expression","volume":"33","author":"Svensson","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"2022031300454266600_B72","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/dom.12000","article-title":"Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials","volume":"15","author":"Monami","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"2022031300454266600_B73","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa1307684","article-title":"Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus","volume":"369","author":"Scirica","year":"2013","journal-title":"N Engl J Med"},{"key":"2022031300454266600_B74","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa1305889","article-title":"Alogliptin after acute coronary syndrome in patients with type 2 diabetes","volume":"369","author":"White","year":"2013","journal-title":"N Engl J Med"},{"key":"2022031300454266600_B75","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJMoa1501352","article-title":"Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes","volume":"373","author":"Green","year":"2015","journal-title":"N Engl J Med"},{"key":"2022031300454266600_B76","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jdiacomp.2014.02.011","article-title":"Lessons from SAVOR and EXAMINE: some important answers, but many open questions","volume":"28","author":"Schernthaner","year":"2014","journal-title":"J Diabetes Complications"},{"key":"2022031300454266600_B77","doi-asserted-by":"crossref","first-page":"e003277","DOI":"10.1161\/JAHA.112.003277","article-title":"Dipeptidyl peptidase-4 inhibitors attenuate endothelial function as evaluated by flow-mediated vasodilatation in type 2 diabetic patients","volume":"2","author":"Ayaori","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2022031300454266600_B78","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/FJC.0000000000000176","article-title":"Protective effects of glucagon-like peptide 1 on endothelial function in hypertension","volume":"65","author":"Liu","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"2022031300454266600_B79","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10557-013-6463-z","article-title":"Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation","volume":"27","author":"Dai","year":"2013","journal-title":"Cardiovasc Drugs Ther"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/65\/1\/239\/580232\/db150122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/65\/1\/239\/580232\/db150122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:46:13Z","timestamp":1667407573000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/65\/1\/239\/34992\/Glucose-Dependent-Insulinotropic-Polypeptide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":79,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,9,22]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db15-0122","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}