{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:07:18Z","timestamp":1790197638436,"version":"4.1.0"},"reference-count":49,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP 53094"],"award-info":[{"award-number":["MOP 53094"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:p>Subjects with impaired glucose tolerance (IGT) have increased myocardial partitioning of dietary fatty acids (DFAs) with left ventricular dysfunction, both of which are improved by modest weight loss over 1 year induced by lifestyle changes. Here, we determined the effects of a 7-day hypocaloric diet (\u2212500 kcal\/day) low in saturated fat (&amp;lt;7% of energy) (LOWCAL study) versus isocaloric with the usual amount saturated fat (\u223c10% of energy) diet (ISOCAL) on DFA metabolism in subjects with IGT. Organ-specific DFA partitioning and cardiac and hepatic DFA fractional uptake rates were measured in 15 IGT subjects (7 males\/8 females) using the oral 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid positron emission tomography method after 7 days of an ISOCAL diet versus a LOWCAL diet using a randomized crossover design. The LOWCAL diet led to reductions in weight and postprandial insulin area under the curve. Myocardial DFA partitioning over 6 h was increased after the LOWCAL diet (2.3 \u00b1 0.1 vs. 1.9 \u00b1 0.2 mean standard uptake value, P &amp;lt; 0.04). However, the early (90\u2013120 min) myocardial DFA fractional uptake was unchanged after the LOWCAL diet (0.055 \u00b1 0.025 vs. 0.046 \u00b1 0.009 min\u22121, P = 0.7). Liver DFA partitioning was unchanged, but liver fractional uptake of DFA tended to be increased. Very short-term caloric and saturated fat dietary restrictions do not lead to the same changes in organ-specific DFA metabolism as those associated with weight loss in subjects with IGT.<\/jats:p>","DOI":"10.2337\/db15-0337","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T02:35:58Z","timestamp":1438223758000},"page":"3690-3699","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":19,"title":["Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects"],"prefix":"10.2337","volume":"64","author":[{"given":"Christophe","family":"Noll","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, 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