{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:05:55Z","timestamp":1792109155553,"version":"4.4.0"},"reference-count":44,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":252,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-033665"],"award-info":[{"award-number":["DK-033665"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and chronic kidney disease\u2013induced fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of diabetic nephropathy in a type 1 diabetic animal model, OVE26. YC-1 [3-(5\u2032-hydroxymethyl-2\u2032-furyl)-1-benzyl indazole], an HIF-1 inhibitor, reduced whole kidney glomerular hypertrophy, mesangial matrix expansion, extracellular matrix accumulation, and urinary albumin excretion as well as NOX4 protein expression and NADPH-dependent reactive oxygen species production, while blood glucose levels remained unchanged. The role of NOX oxidases in HIF-1\u2013mediated extracellular matrix accumulation was explored in vitro using glomerular mesangial cells. Through a series of genetic silencing and adenoviral overexpression studies, we have defined GLUT1 as a critical downstream target of HIF-1\u03b1 mediating high glucose\u2013induced matrix expression through the NADPH oxidase isoform, NOX4. Together, our data suggest that pharmacological inhibition of HIF-1 may improve clinical manifestations of diabetic nephropathy.<\/jats:p>","DOI":"10.2337\/db15-0519","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T04:28:49Z","timestamp":1456288129000},"page":"1387-1397","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":120,"title":["HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice"],"prefix":"10.2337","volume":"65","author":[{"given":"Bijaya K.","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthigayan","family":"Shanmugasundaram","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Friedrichs","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Cavaglierii","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandakini","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX"},{"name":"Audie L. 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