{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:12:03Z","timestamp":1762866723616,"version":"3.37.3"},"reference-count":13,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK-57136"],"award-info":[{"award-number":["DK-57136"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight\/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association. Look AHEAD is a randomized, controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Look AHEAD participants included in this report were 3,845 overweight\/obese individuals with T2D who provided consent for genetic analyses. Over a median of 9.6 years of follow-up, the risk (C) allele for GLUL rs10911021 was significantly associated with the primary composite end point of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina among individuals with no history of cardiovascular disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01\u20131.36]; P = 0.032). Results appeared more consistent in recessive models and among individuals with no known history of CVD at baseline; ILI did not alter these associations. These results extend the association of GLUL rs10911021 to incident CVD morbidity and mortality in the setting of T2D.<\/jats:p>","DOI":"10.2337\/db15-0890","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T03:38:16Z","timestamp":1442979496000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":26,"title":["Prospective Association of <i>GLUL<\/i> rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study"],"prefix":"10.2337","volume":"65","author":[{"name":"The Look AHEAD Research Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"2022031300461341500_B1","first-page":"e28","article-title":"Heart disease and stroke statistics--2014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"2022031300461341500_B2"},{"key":"2022031300461341500_B3","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.2337\/db14-1653","article-title":"Genetic variant at the GLUL locus predicts all-cause mortality in patients with type 2 diabetes","volume":"64","author":"Prudente","year":"2015","journal-title":"Diabetes"},{"key":"2022031300461341500_B4"},{"key":"2022031300461341500_B5"},{"key":"2022031300461341500_B6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0197-2456(03)00064-3","article-title":"Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes","volume":"24","author":"Ryan","year":"2003","journal-title":"Control Clin Trials"},{"key":"2022031300461341500_B7"},{"key":"2022031300461341500_B8"},{"key":"2022031300461341500_B9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/sim.1599","article-title":"Modelling clustered survival data from multicentre clinical trials","volume":"23","author":"Glidden","year":"2004","journal-title":"Stat Med"},{"key":"2022031300461341500_B10"},{"key":"2022031300461341500_B11"},{"key":"2022031300461341500_B12"},{"doi-asserted-by":"crossref","unstructured":"Mansour A, Mohajeri-Tehrani MR, Qorbani M, Heshmat R, Larijani B, Hosseini S. Effect of glutamine supplementation on cardiovascular risk factors in patients with type 2 diabetes. Nutrition 2015;31:119\u2013126","key":"2022031300461341500_B13","DOI":"10.1016\/j.nut.2014.05.014"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/65\/1\/297\/580171\/db150890.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/65\/1\/297\/580171\/db150890.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:47:57Z","timestamp":1667407677000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/65\/1\/297\/35004\/Prospective-Association-of-GLUL-rs10911021-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,9,22]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db15-0890","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}