{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:03:34Z","timestamp":1772823814521,"version":"3.50.1"},"reference-count":36,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["CRC 1052 \u201cObesity Mechanisms\u201d projects"],"award-info":[{"award-number":["CRC 1052 \u201cObesity Mechanisms\u201d projects"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["A01"],"award-info":[{"award-number":["A01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["IFB AdiposityDiseases, grant no. 01EO1501"],"award-info":[{"award-number":["IFB AdiposityDiseases, grant no. 01EO1501"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung","award":["82DZD00601"],"award-info":[{"award-number":["82DZD00601"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:p>Lipodystrophy (LD) is a rare disease with a paucity of subcutaneous adipocytes and leptin deficiency. Patients often develop severe diabetes and, additionally, show a disturbed eating behavior with reduced satiety. The disturbed eating behavior can be restored by substitution with the leptin analog metreleptin. Long-term effects of metreleptin on resting state brain connectivity in treatment-naive patients with LD have not been assessed. In this study, resting state functional MRI scans and extensive behavioral testing assessing changes in hunger\/satiety regulation were performed during the first 52 weeks of metreleptin treatment in nine patients with LD. Resting state connectivity significantly increased over the course of metreleptin treatment in three brain areas (i.e., hypothalamus, insula\/superior temporal gyrus, medial prefrontal cortex). Behavioral tests demonstrated that perceived hunger, importance of eating, eating frequencies, and liking ratings of food pictures significantly decreased during metreleptin therapy. Taken together, leptin substitution was accompanied by long-term changes of hedonic and homeostatic central nervous networks regulating eating behavior as well as decreased hunger feelings and diminished incentive value of food. Future studies need to assess whether metreleptin treatment in LD restores physiological processes important for the development of satiety.<\/jats:p>","DOI":"10.2337\/db15-1550","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T04:19:14Z","timestamp":1462940354000},"page":"2179-2186","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":35,"title":["Leptin Substitution in Patients With Lipodystrophy: Neural Correlates for Long-term Success in the Normalization of Eating Behavior"],"prefix":"10.2337","volume":"65","author":[{"given":"Haiko","family":"Schl\u00f6gl","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Horstmann","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Integrated Research and Treatment Center AdiposityDiseases, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstanze","family":"Miehle","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janett","family":"P\u00fcschel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Leipzig, Leipzig, Germany"},{"name":"Integrated Research and Treatment Center AdiposityDiseases, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Villringer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Pleger","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Department of Neurology, BG University Clinic Bergmannsheil, Ruhr University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stumvoll","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Fasshauer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Leipzig, Leipzig, Germany"},{"name":"Integrated Research and Treatment Center AdiposityDiseases, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"2022031300055557400_B1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00108-010-2711-5","article-title":"Lipodystrophy. 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