{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:09:43Z","timestamp":1792548583707,"version":"4.5.0"},"reference-count":41,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100003194","name":"New York Stem Cell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000901","name":"JDRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-104216"],"award-info":[{"award-number":["DK-104216"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-104119"],"award-info":[{"award-number":["DK-104119"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. 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Here we show that gastrin, a stomach hormone typically expressed in the pancreas only during embryogenesis, is expressed in islets of diabetic rodents and humans with T2D. Although gastrin in mice is expressed in insulin+ cells, gastrin expression in humans with T2D occurs in both insulin+ and somatostatin+ cells. Genetic lineage tracing in mice indicates that gastrin expression is turned on in a subset of differentiated \u03b2-cells after exposure to severe hyperglycemia. Gastrin expression in adult \u03b2-cells does not involve the endocrine progenitor cell regulator neurogenin3 but requires membrane depolarization, calcium influx, and calcineurin signaling. In vivo and in vitro experiments show that gastrin expression is rapidly eliminated upon exposure of \u03b2-cells to normal glucose levels. These results reveal the fetal hormone gastrin as a novel marker for reversible human \u03b2-cell reprogramming in diabetes.<\/jats:p>","DOI":"10.2337\/db16-0641","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T22:10:28Z","timestamp":1479507028000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":63,"title":["Pancreatic \u03b2-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes"],"prefix":"10.2337","volume":"66","author":[{"given":"Tehila","family":"Dahan","sequence":"first","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Ziv","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer 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