{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:11:12Z","timestamp":1785208272830,"version":"3.55.0"},"reference-count":68,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p>A link between excess dietary sugar and cardiac disease is clearly evident and has been largely attributed to systemic metabolic dysregulation. Now a new paradigm is emerging, and a compelling case can be made that fructose-associated heart injury may be attributed to the direct actions of fructose on cardiomyocytes. Plasma and cardiac fructose levels are elevated in patients with diabetes, and evidence suggests that some unique properties of fructose (vs. glucose) have specific cardiomyocyte consequences. Investigations to date have demonstrated that cardiomyocytes have the capacity to transport and utilize fructose and express all of the necessary proteins for fructose metabolism. When dietary fructose intake is elevated and myocardial glucose uptake compromised by insulin resistance, increased cardiomyocyte fructose flux represents a hazard involving unregulated glycolysis and oxidative stress. The high reactivity of fructose supports the contention that fructose accelerates subcellular hexose sugar-related protein modifications, such as O-GlcNAcylation and advanced glycation end product formation. Exciting recent discoveries link heart failure to induction of the specific high-affinity fructose-metabolizing enzyme, fructokinase, in an experimental setting. In this Perspective, we review key recent findings to synthesize a novel view of fructose as a cardiopathogenic agent in diabetes and to identify important knowledge gaps for urgent research focus.<\/jats:p>","DOI":"10.2337\/db16-0682","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T20:30:21Z","timestamp":1479846621000},"page":"3521-3528","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":46,"title":["Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology"],"prefix":"10.2337","volume":"65","author":[{"given":"Lea M.D.","family":"Delbridge","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky L.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca H.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Heart Failure Pharmacology, Baker IDI Heart and Diabetes Institute, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley M.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Melbourne, Victoria, Australia"},{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"},{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"2022031300482785500_B1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.107.689935","article-title":"Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community","volume":"116","author":"Dhingra","year":"2007","journal-title":"Circulation"},{"key":"2022031300482785500_B2","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.2337\/dc10-1079","article-title":"Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis","volume":"33","author":"Malik","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031300482785500_B3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.mayocp.2014.12.019","article-title":"Added fructose: a principal driver of type 2 diabetes mellitus and its consequences","volume":"90","author":"DiNicolantonio","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"2022031300482785500_B4","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.2337\/db12-1814","article-title":"Sugar, uric acid, and the etiology of diabetes and obesity","volume":"62","author":"Johnson","year":"2013","journal-title":"Diabetes"},{"key":"2022031300482785500_B5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1139\/Y10-005","article-title":"Elevated dietary sugar and the heart: experimental models and myocardial remodeling","volume":"88","author":"Mellor","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"2022031300482785500_B6","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"2022031300482785500_B7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2022031300482785500_B8","doi-asserted-by":"crossref","first-page":"R1198","DOI":"10.1152\/ajpregu.00262.2014","article-title":"Overnutrition, mTOR signaling, and cardiovascular diseases","volume":"307","author":"Jia","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2022031300482785500_B9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"key":"2022031300482785500_B10","doi-asserted-by":"crossref","first-page":"1228S","DOI":"10.3945\/jn.108.098277","article-title":"National estimates of dietary fructose intake increased from 1977 to 2004 in the United States","volume":"139","author":"Marriott","year":"2009","journal-title":"J Nutr"},{"key":"2022031300482785500_B11","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1038\/ncomms3434","article-title":"Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome","volume":"4","author":"Lanaspa","year":"2013","journal-title":"Nat Commun"},{"key":"2022031300482785500_B12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/502181a","article-title":"Metabolic syndrome: F stands for fructose and fat","volume":"502","author":"Lyssiotis","year":"2013","journal-title":"Nature"},{"key":"2022031300482785500_B13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3945\/an.114.008177","article-title":"Fructose-containing sugars and cardiovascular disease","volume":"6","author":"Rippe","year":"2015","journal-title":"Adv Nutr"},{"key":"2022031300482785500_B14","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3945\/ajcn.114.100461","article-title":"A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid\/lipoprotein risk factors for cardiovascular disease in young adults","volume":"101","author":"Stanhope","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"2022031300482785500_B15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/jch.12457","article-title":"Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption","volume":"17","author":"Angelopoulos","year":"2015","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2022031300482785500_B16","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.109.876185","article-title":"Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk","volume":"121","author":"Malik","year":"2010","journal-title":"Circulation"},{"key":"2022031300482785500_B17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S2213-8587(15)00044-3","article-title":"Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials","volume":"3","author":"Udell","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022031300482785500_B18"},{"key":"2022031300482785500_B19","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.yjmcc.2011.03.002","article-title":"Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice","volume":"50","author":"Mellor","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"2022031300482785500_B20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cbf.2982","article-title":"Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome","volume":"32","author":"Cheng","year":"2014","journal-title":"Cell Biochem Funct"},{"key":"2022031300482785500_B21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s00259-006-0267-3","article-title":"Assessment of insulin resistance in fructose-fed rats with 125I-6-deoxy-6-iodo-D-glucose, a new tracer of glucose transport","volume":"34","author":"Perret","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2022031300482785500_B22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijcard.2016.03.239","article-title":"High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy","volume":"215","author":"Huang","year":"2016","journal-title":"Int J Cardiol"},{"key":"2022031300482785500_B23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1440-1681.2009.05274.x","article-title":"Reactive oxygen species and insulin-resistant cardiomyopathy","volume":"37","author":"Mellor","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2022031300482785500_B24","doi-asserted-by":"crossref","first-page":"e104971","DOI":"10.1371\/journal.pone.0104971","article-title":"Loss of Intralipid\u00ae- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling","volume":"9","author":"Lou","year":"2014","journal-title":"PLoS One"},{"key":"2022031300482785500_B25","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.nut.2009.08.017","article-title":"High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy","volume":"26","author":"Mellor","year":"2010","journal-title":"Nutrition"},{"key":"2022031300482785500_B26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11010-005-4778-1","article-title":"Early pre-diabetic state alters adaptation of myocardial glucose metabolism during ischemia in rats","volume":"272","author":"Morel","year":"2005","journal-title":"Mol Cell Biochem"},{"key":"2022031300482785500_B27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1124\/jpet.103.055970","article-title":"Fructose-fed rats are protected against ischemia\/reperfusion injury","volume":"307","author":"Jordan","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"2022031300482785500_B28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/153537020623100411","article-title":"Fructose-fed rat hearts are protected against ischemia-reperfusion injury","volume":"231","author":"Joyeux-Faure","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"2022031300482785500_B29","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.4161\/auto.7.10.17148","article-title":"Autophagy anomalies in the diabetic myocardium","volume":"7","author":"Mellor","year":"2011","journal-title":"Autophagy"},{"key":"2022031300482785500_B30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1440-1681.2012.05738.x","article-title":"Myocardial insulin resistance, metabolic stress and autophagy in diabetes","volume":"40","author":"Mellor","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2022031300482785500_B31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.lfs.2012.03.042","article-title":"Autophagic predisposition in the insulin resistant diabetic heart","volume":"92","author":"Mellor","year":"2013","journal-title":"Life Sci"},{"key":"2022031300482785500_B32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.bjp.0707223","article-title":"Aminoguanidine prevents fructose-induced deterioration in left ventricular-arterial coupling in Wistar rats","volume":"151","author":"Chang","year":"2007","journal-title":"Br J Pharmacol"},{"key":"2022031300482785500_B33","doi-asserted-by":"crossref","first-page":"H964","DOI":"10.1152\/ajpheart.00797.2011","article-title":"Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness","volume":"302","author":"Mellor","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022031300482785500_B34","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijcard.2015.09.022","article-title":"Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate","volume":"202","author":"Sommese","year":"2016","journal-title":"Int J Cardiol"},{"key":"2022031300482785500_B35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/diacare.25.2.353","article-title":"Increased fructose concentrations in blood and urine in patients with diabetes","volume":"25","author":"Kawasaki","year":"2002","journal-title":"Diabetes Care"},{"key":"2022031300482785500_B36","doi-asserted-by":"crossref","first-page":"e25204","DOI":"10.1371\/journal.pone.0025204","article-title":"Fructose modulates cardiomyocyte excitation-contraction coupling and Ca\u00b2\u207a handling in vitro","volume":"6","author":"Mellor","year":"2011","journal-title":"PLoS One"},{"key":"2022031300482785500_B37","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature14508","article-title":"HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease","volume":"522","author":"Mirtschink","year":"2015","journal-title":"Nature"},{"key":"2022031300482785500_B38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s11906-014-0434-z","article-title":"Fructose and uric acid: is there a role in endothelial function?","volume":"16","author":"Jia","year":"2014","journal-title":"Curr Hypertens Rep"},{"key":"2022031300482785500_B39","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1681\/ASN.2013080901","article-title":"Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy","volume":"25","author":"Lanaspa","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2022031300482785500_B40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0026-0495(92)90283-G","article-title":"Increase in cardiac muscle fructose content in streptozotocin-induced diabetic rats","volume":"41","author":"Kashiwagi","year":"1992","journal-title":"Metabolism"},{"key":"2022031300482785500_B41","doi-asserted-by":"crossref","first-page":"754S","DOI":"10.1093\/ajcn\/58.5.754S","article-title":"Intermediary metabolism of fructose","volume":"58","author":"Mayes","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"2022031300482785500_B42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"2022031300482785500_B43","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.lfs.2012.08.006","article-title":"Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart","volume":"92","author":"McLarty","year":"2013","journal-title":"Life Sci"},{"key":"2022031300482785500_B44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yjmcc.2012.11.008","article-title":"Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway","volume":"55","author":"Lauzier","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2022031300482785500_B45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.mie.2015.06.026","article-title":"Metabolic tracing using stable isotope-labeled substrates and mass spectrometry in the perfused mouse heart","volume":"561","author":"Ruiz","year":"2015","journal-title":"Methods Enzymol"},{"key":"2022031300482785500_B46","doi-asserted-by":"crossref","first-page":"34449","DOI":"10.1074\/jbc.R114.585984","article-title":"Protein O-GlcNAcylation and cardiovascular (patho)physiology","volume":"289","author":"Marsh","year":"2014","journal-title":"J Biol Chem"},{"key":"2022031300482785500_B47","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/01.RES.0000165478.06813.58","article-title":"Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart","volume":"96","author":"Hu","year":"2005","journal-title":"Circ Res"},{"key":"2022031300482785500_B48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1152\/japplphysiol.00147.2011","article-title":"Swim-exercised mice show a decreased level of protein O-GlcNAcylation and expression of O-GlcNAc transferase in heart","volume":"111","author":"Belke","year":"2011","journal-title":"J Appl Physiol (1985)"},{"key":"2022031300482785500_B49","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"2022031300482785500_B50","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/mrd.20480","article-title":"Hexose-specificity of hexokinase and ADP-dependence of pyruvate kinase play important roles in the control of monosaccharide utilization in freshly diluted boar spermatozoa","volume":"73","author":"Medrano","year":"2006","journal-title":"Mol Reprod Dev"},{"key":"2022031300482785500_B51","doi-asserted-by":"crossref","first-page":"e26583","DOI":"10.1371\/journal.pone.0026583","article-title":"Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells","volume":"6","author":"Hirahatake","year":"2011","journal-title":"PLoS One"},{"key":"2022031300482785500_B52","doi-asserted-by":"crossref","first-page":"E959","DOI":"10.1152\/ajpendo.00202.2012","article-title":"Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets","volume":"303","author":"Hecker","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022031300482785500_B53","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.RES.0000065620.39919.20","article-title":"A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes","volume":"92","author":"Candido","year":"2003","journal-title":"Circ Res"},{"key":"2022031300482785500_B54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCULATIONAHA.107.728550","article-title":"Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension","volume":"117","author":"van Heerebeek","year":"2008","journal-title":"Circulation"},{"key":"2022031300482785500_B55","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2337\/diabetes.52.7.1825","article-title":"Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors\/calcium-release channels","volume":"52","author":"Bidasee","year":"2003","journal-title":"Diabetes"},{"key":"2022031300482785500_B56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2337\/diabetes.53.2.463","article-title":"Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase","volume":"53","author":"Bidasee","year":"2004","journal-title":"Diabetes"},{"key":"2022031300482785500_B57","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2174\/092986707780830989","article-title":"The road to advanced glycation end products: a mechanistic perspective","volume":"14","author":"Cho","year":"2007","journal-title":"Curr Med Chem"},{"key":"2022031300482785500_B58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/dmrr.488","article-title":"Fructose-mediated non-enzymatic glycation: sweet coupling or bad modification","volume":"20","author":"Schalkwijk","year":"2004","journal-title":"Diabetes Metab Res Rev"},{"key":"2022031300482785500_B59","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1475-2840-13-78","article-title":"Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE\/PI3K\/AKT\/mTOR pathway","volume":"13","author":"Hou","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"2022031300482785500_B60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000364779","article-title":"Effects of advanced glycation end products on calcium handling in cardiomyocytes","volume":"129","author":"Yan","year":"2014","journal-title":"Cardiology"},{"key":"2022031300482785500_B61","doi-asserted-by":"crossref","first-page":"H2587","DOI":"10.1152\/ajpheart.00516.2003","article-title":"Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart","volume":"285","author":"Liu","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022031300482785500_B62","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1016\/S0021-9258(19)84904-9","article-title":"Nonenzymatic glycation of bovine serum albumin by fructose (fructation). Comparison with the Maillard reaction initiated by glucose","volume":"264","author":"Su\u00e1rez","year":"1989","journal-title":"J Biol Chem"},{"key":"2022031300482785500_B63","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.12192669","article-title":"Reaction of monosaccharides with proteins: possible evolutionary significance","volume":"213","author":"Bunn","year":"1981","journal-title":"Science"},{"key":"2022031300482785500_B64","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1021\/bi00406a016","article-title":"Role of fructose in glycation and cross-linking of proteins","volume":"27","author":"McPherson","year":"1988","journal-title":"Biochemistry"},{"key":"2022031300482785500_B65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/labinvest.2010.62","article-title":"Immunological detection of fructose-derived advanced glycation end-products","volume":"90","author":"Takeuchi","year":"2010","journal-title":"Lab Invest"},{"key":"2022031300482785500_B66","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1074\/jbc.273.10.5885","article-title":"Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle","volume":"273","author":"Ferrington","year":"1998","journal-title":"J Biol Chem"},{"key":"2022031300482785500_B67","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/cvr\/cvm019","article-title":"Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum","volume":"77","author":"Shimura","year":"2008","journal-title":"Cardiovasc Res"},{"key":"2022031300482785500_B68","first-page":"125","article-title":"Experimental studies on the role of fructose in the development of diabetic complications","volume":"48","author":"Sakai","year":"2002","journal-title":"Kobe J Med Sci"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/diabetes.diabetesjournals.org\/syndication\/doi\/10.2337\/db16-0682","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/65\/12\/3521\/417556\/db160682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/65\/12\/3521\/417556\/db160682.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:30:51Z","timestamp":1667406651000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/65\/12\/3521\/35056\/Diabetic-Cardiomyopathy-The-Case-for-a-Role-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,12]]},"references-count":68,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,11,12]]},"published-print":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db16-0682","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,12]]}}}