{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:42:32Z","timestamp":1789900952261,"version":"4.0.1"},"reference-count":42,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-97742"],"award-info":[{"award-number":["MOP-97742"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-86450"],"award-info":[{"award-number":["MOP-86450"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-93650, MOP-106688 and MOP-84363"],"award-info":[{"award-number":["MOP-93650, MOP-106688 and MOP-84363"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["HL-48455"],"award-info":[{"award-number":["HL-48455"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"crossref","award":["KFOC120008"],"award-info":[{"award-number":["KFOC120008"]}],"id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007476","name":"Canadian Diabetes Association","doi-asserted-by":"publisher","award":["NOD_OG-3-14-4472-JC"],"award-info":[{"award-number":["NOD_OG-3-14-4472-JC"]}],"id":[{"id":"10.13039\/100007476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:p>We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db\/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db\/db mice developed hyperglycemia, oxidative stress, and nephropathy at age 20 weeks compared with their db\/m littermates. These abnormalities, with the exception of hyperglycemia, were attenuated in db\/db\u2008hnRNP F\u2013transgenic (Tg) mice specifically overexpressing hnRNP F in their RPTCs. Sirtuin-1, Foxo3\u03b1, and catalase expression were significantly decreased in RPTCs from db\/db mice and normalized in db\/db\u2008hnRNP F\u2013Tg mice. In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3\u03b1 with downregulation of acetylated p53 expression and prevented downregulation of Sirtuin-1 and Foxo3\u03b1 expression in IRPTCs by high glucose plus palmitate. Transfection of Sirtuin-1 small interfering RNA prevented hnRNP F stimulation of Foxo3\u03b1 and downregulation of acetylated p53 expression. hnRNP F stimulated Sirtuin-1 transcription via hnRNP F\u2013responsive element in the Sirtuin-1 promoter. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3\u03b1 than nondiabetic kidneys. Our results demonstrate that hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.<\/jats:p>","DOI":"10.2337\/db16-1588","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:30:25Z","timestamp":1492648225000},"page":"1964-1978","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":39,"title":["Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice"],"prefix":"10.2337","volume":"66","author":[{"given":"Chao-Sheng","family":"Lo","sequence":"first","affiliation":[{"name":"Centre de recherche, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM) and D\u00e9partement de m\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montreal, QC, 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