{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:28:05Z","timestamp":1788316085040,"version":"build-2803163510"},"reference-count":34,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["Korean Health Technology R&D Project (HI13C0715)"],"award-info":[{"award-number":["Korean Health Technology R&D Project (HI13C0715)"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:p>Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of \u03b2-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model\u2013based insulin secretion indices were estimated by using a 2-h seven-sample oral glucose tolerance test. Insulin secretion by INS-1E \u03b2-cells was measured after 48 h of treatment with three OCPs or one PCB mixture. Static second-phase insulin secretion significantly decreased with increasing serum concentrations of OCPs. Adjusted means were 63.2, 39.3, 44.1, 39.3, 39.7, and 22.3 across six categories of a summary measure of OCPs (Ptrend = 0.02). Dynamic first-phase insulin secretion remarkably decreased with increasing concentrations of OCPs among only insulin-sensitive individuals (Ptrend = 0.02); the insulin levels among individuals with high OCPs were \u223c30% of those with low OCPs. Compared with OCPs, PCBs showed weaker associations. The decreased insulin secretion by INS-1E \u03b2-cells was observed for even 1 pmol\/L OCP. The data from human and in vitro cell experiments suggest that chronic exposure to low-dose POPs, especially OCPs, can induce pancreatic \u03b2-cell dysfunction.<\/jats:p>","DOI":"10.2337\/db17-0188","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:20:15Z","timestamp":1500423615000},"page":"2669-2680","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":77,"title":["Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic \u03b2-Cells: Human and In Vitro Evidence"],"prefix":"10.2337","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3206-7894","authenticated-orcid":false,"given":"Yu-Mi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of 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