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GATA6 mutations have also recently been linked to adult-onset diabetes, with subclinical or no exocrine insufficiency, suggesting an important role for GATA6 in human \u03b2-cell physiology. To investigate the role of GATA6 in the adult endocrine pancreas, we generated mice in which Gata6 is specifically inactivated in the pancreas. These mice develop glucose intolerance. Islets deficient in GATA6 activity display decreased insulin content and impaired insulin secretion. Gata6-deficient \u03b2-cells exhibit ultrastructural abnormalities, including increased immature insulin granules, swollen mitochondria, and disorganized endoplasmic reticulum. We also demonstrate that Pdx1 expression in adult \u03b2-cells depends on GATA sites in transgenic reporter mice and that loss of GATA6 greatly affects \u03b2-cell\u2013specific gene expression. These findings demonstrate the essential role of GATA6 in \u03b2-cell function.<\/jats:p>","DOI":"10.2337\/db17-0364","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T01:21:10Z","timestamp":1513819270000},"page":"448-460","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":26,"title":["GATA6 Controls Insulin Biosynthesis and Secretion in Adult \u03b2-Cells"],"prefix":"10.2337","volume":"67","author":[{"given":"Laura","family":"Villamayor","sequence":"first","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa (CABIMER), Universidad Pablo de Olavide, Universidad de Sevilla, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Rodr\u00edguez-Seguel","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina 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