{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:58:00Z","timestamp":1791917880158,"version":"4.3.4"},"reference-count":50,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770827"],"award-info":[{"award-number":["81770827"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81471034"],"award-info":[{"award-number":["81471034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81370910"],"award-info":[{"award-number":["81370910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670764"],"award-info":[{"award-number":["81670764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"863 Program for Young Scientists","award":["S2015AA020927"],"award-info":[{"award-number":["S2015AA020927"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2016B020238001"],"award-info":[{"award-number":["2016B020238001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Fund for Science and Technology Development of Guangdong Province","award":["2016A01010301"],"award-info":[{"award-number":["2016A01010301"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>Diabetic wounds are recalcitrant to healing. However, the mechanism causing this dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) is indicative of poor wound healing. In this study, we show that specificity protein-1 (Sp1), a regulator of MMP-9, binds directly to its promoter and enhances its expression. Additionally, we demonstrated that Sp1 is the direct target of two microRNAs (miRNAs), miR-129 and -335, which are significantly downregulated in diabetic skin tissues. In vitro experiments confirmed that miR-129 or -335 overexpression inhibits MMP-9 promoter activity and protein expression by targeting Sp1, whereas the inhibition of these miRNAs has the opposite effect. The beneficial role of miR-129 or miR-335 in diabetic wound healing was confirmed by the topical administration of miRNA agomirs in diabetic animals. This treatment downregulated Sp1-mediated MMP-9 expression, increased keratinocyte migration, and recovered skin thickness and collagen content. The combined treatment with miR-129 and miR-335 induced a synergistic effect on Sp1 repression and MMP-9 downregulation both in vitro and in vivo. This study demonstrates the regulatory mechanism of Sp1-mediated MMP-9 expression in diabetic wound healing and highlights the potential therapeutic benefits of miR-129 and -335 in delayed wound healing in diabetes.<\/jats:p>","DOI":"10.2337\/db17-1238","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T15:30:13Z","timestamp":1525966213000},"page":"1627-1638","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":149,"title":["MicroRNA-129 and -335 Promote Diabetic Wound Healing by Inhibiting Sp1-Mediated MMP-9 Expression"],"prefix":"10.2337","volume":"67","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"China Diabetes-Related Chronic Wound Treatment Training Center, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo juan","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"China Diabetes-Related Chronic Wound Treatment Training Center, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"China Diabetes-Related Chronic Wound Treatment Training Center, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng die","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting ting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"China Diabetes-Related Chronic Wound Treatment Training Center, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-1449","authenticated-orcid":false,"given":"Meng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People\u2019s Republic of China"},{"name":"China Diabetes-Related Chronic Wound Treatment Training Center, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"2022031211383370200_B1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.dsx.2015.04.007","article-title":"Diabetic foot ulcer\u2013a review on pathophysiology, classification and microbial etiology","volume":"9","author":"Noor","year":"2015","journal-title":"Diabetes Metab Syndr"},{"key":"2022031211383370200_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/dfa.v3i0.18409","article-title":"Diabetic foot infections: current concept review","volume":"3","author":"Hobizal","year":"2012","journal-title":"Diabet Foot Ankle"},{"key":"2022031211383370200_B3","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.12968\/jowc.2017.26.Sup4.S4","article-title":"Cost-of-illness studies in chronic ulcers: a systematic review","volume":"26","author":"Chan","year":"2017","journal-title":"J Wound Care"},{"key":"2022031211383370200_B4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2017.7263","article-title":"Redox signaling in diabetic wound healing regulates extracellular matrix deposition","volume":"27","author":"Kunkemoeller","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"2022031211383370200_B5","first-page":"2043","article-title":"New intracellular activities of matrix metalloproteinases shine in the moonlight","volume-title":"Biochim Biophys Acta","author":"Jobin","year":"2017"},{"key":"2022031211383370200_B6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/wound.2011.0344","article-title":"Growth factor-extracellular matrix interactions regulate wound repair","volume":"1","author":"Wilgus","year":"2012","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2022031211383370200_B7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1464-5491.2008.02414.x","article-title":"Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing","volume":"25","author":"Muller","year":"2008","journal-title":"Diabet Med"},{"key":"2022031211383370200_B8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/wrr.12035","article-title":"Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin","volume":"21","author":"Serra","year":"2013","journal-title":"Wound Repair Regen"},{"key":"2022031211383370200_B9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1365-2133.2008.08462.x","article-title":"Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer","volume":"158","author":"Rayment","year":"2008","journal-title":"Br J Dermatol"},{"key":"2022031211383370200_B10","doi-asserted-by":"crossref","first-page":"15226","DOI":"10.1073\/pnas.1517847112","article-title":"Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy","volume":"112","author":"Gao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031211383370200_B11","doi-asserted-by":"crossref","first-page":"17417","DOI":"10.1021\/acsami.7b02809","article-title":"Efficiency and safety of \u03b2-CD-(D3)7 as siRNA carrier for decreasing matrix metalloproteinase-9 expression and improving wound healing in diabetic rats","volume":"9","author":"Li","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"2022031211383370200_B12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00441-012-1410-z","article-title":"Matrix metalloproteinases and epidermal wound repair","volume":"351","author":"Martins","year":"2013","journal-title":"Cell Tissue Res"},{"key":"2022031211383370200_B13","doi-asserted-by":"crossref","first-page":"14064","DOI":"10.1016\/S0021-9258(18)92810-3","article-title":"Transcriptional and post-transcriptional regulation of 72-kDa gelatinase\/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression","volume":"266","author":"Overall","year":"1991","journal-title":"J Biol Chem"},{"key":"2022031211383370200_B14","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1021\/bi00067a018","article-title":"Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: evidence for involvement of delayed transcriptional activation and enhanced mRNA stability","volume":"32","author":"Shapiro","year":"1993","journal-title":"Biochemistry"},{"key":"2022031211383370200_B15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/JME-12-0172","article-title":"Role of site-specific DNA demethylation in TNF\u03b1-induced MMP9 expression in keratinocytes","volume":"50","author":"Ling","year":"2013","journal-title":"J Mol Endocrinol"},{"key":"2022031211383370200_B16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"2022031211383370200_B17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"2022031211383370200_B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-013-1787-3","article-title":"MicroRNAs and human diseases: diagnostic and therapeutic potential","volume":"358","author":"Maqbool","year":"2014","journal-title":"Cell Tissue Res"},{"key":"2022031211383370200_B19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/exd.12361","article-title":"Activation of toll-like receptors alters the microRNA expression profile of keratinocytes","volume":"23","author":"Meisgen","year":"2014","journal-title":"Exp Dermatol"},{"key":"2022031211383370200_B20","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1159\/000447913","article-title":"MicroRNA-129 in human cancers: from tumorigenesis to clinical treatment","volume":"39","author":"Gao","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"2022031211383370200_B21","first-page":"1481","article-title":"miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer","volume":"7","author":"Fesler","year":"2014","journal-title":"OncoTargets Ther"},{"key":"2022031211383370200_B22","first-page":"15399","article-title":"Diverse roles of miR-335 in development and progression of cancers","volume-title":"Tumour Biol","author":"Luo","year":"2016"},{"key":"2022031211383370200_B23","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.3892\/ol.2017.5818","article-title":"MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol Lett"},{"key":"2022031211383370200_B24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/cen.13047","article-title":"\u03b1-ketoglutarate is associated with delayed wound healing in diabetes","volume":"85","author":"Tan","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2022031211383370200_B25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3928\/0147-7447-19870101-28","article-title":"The diabetic foot","volume":"10","author":"Wagner","year":"1987","journal-title":"Orthopedics"},{"key":"2022031211383370200_B26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/wrr.12426","article-title":"AGE-induced keratinocyte MMP-9 expression is linked to TET2-mediated CpG demethylation","volume":"24","author":"Zhang","year":"2016","journal-title":"Wound Repair Regen"},{"key":"2022031211383370200_B27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0625.2011.01408.x","article-title":"Involvement of RAGE, MAPK and NF-\u03baB pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes","volume":"21","author":"Zhu","year":"2012","journal-title":"Exp Dermatol"},{"key":"2022031211383370200_B28","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.7150\/thno.19893","article-title":"Combination of AAV-TRAIL with miR-221-zip therapeutic strategy overcomes the resistance to TRAIL induced apoptosis in liver cancer","volume":"7","author":"Ma","year":"2017","journal-title":"Theranostics"},{"key":"2022031211383370200_B29","doi-asserted-by":"crossref","first-page":"e1006244","DOI":"10.1371\/journal.pgen.1006244","article-title":"Reprogramming of normal fibroblasts into cancer-associated fibroblasts by miRNAs-mediated CCL2\/VEGFA signaling","volume":"12","author":"Shen","year":"2016","journal-title":"PLoS Genet"},{"key":"2022031211383370200_B30","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1093\/nar\/gkx317","article-title":"Identification of miRNA-7 by genome-wide analysis as a critical sensitizer for TRAIL-induced apoptosis in glioblastoma cells","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2022031211383370200_B31","doi-asserted-by":"crossref","first-page":"18611","DOI":"10.1073\/pnas.1013942107","article-title":"Acceleration of wound healing by growth hormone-releasing hormone and its agonists","volume":"107","author":"Dioufa","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031211383370200_B32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1534734617696728","article-title":"Expression and influence of matrix metalloproteinase-9\/tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor in diabetic foot ulcers","volume":"16","author":"Li","year":"2017","journal-title":"Int J Low Extrem Wounds"},{"key":"2022031211383370200_B33","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.2337\/dc09-1394","article-title":"Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers: response to Muller et al","volume":"32","author":"Liu","year":"2009","journal-title":"Diabetes Care"},{"key":"2022031211383370200_B34","doi-asserted-by":"crossref","first-page":"20978","DOI":"10.1074\/jbc.M113.457903","article-title":"Matrix metalloproteinase (MMP) 9 transcription in mouse brain induced by fear learning","volume":"288","author":"Ganguly","year":"2013","journal-title":"J Biol Chem"},{"key":"2022031211383370200_B35","doi-asserted-by":"crossref","first-page":"L89","DOI":"10.1152\/ajplung.00060.2012","article-title":"Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice","volume":"303","author":"Xu","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2022031211383370200_B36","first-page":"1761","article-title":"Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy","volume-title":"Biochim Biophys Acta","author":"Mishra","year":"2017"},{"key":"2022031211383370200_B37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.yexmp.2016.04.005","article-title":"Synergistic effects of c-Jun and SP1 in the promotion of TGF\u03b21-mediated diabetic nephropathy progression","volume":"100","author":"Gao","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"2022031211383370200_B38","doi-asserted-by":"crossref","first-page":"543818","DOI":"10.1155\/2015\/543818","article-title":"Altered expression of NF- \u03ba B and SP1 after exposure to advanced glycation end-products and effects of neurotrophic factors in AGEs exposed rat retinas","volume":"2015","author":"Bikbova","year":"2015","journal-title":"J Diabetes Res"},{"key":"2022031211383370200_B39","doi-asserted-by":"crossref","first-page":"25062","DOI":"10.1074\/jbc.M109.099655","article-title":"Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1","volume":"285","author":"Murthy","year":"2010","journal-title":"J Biol Chem"},{"key":"2022031211383370200_B40","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0006-291X(02)02283-0","article-title":"Evidence for the role of promoter methylation in the regulation of MMP-9 gene expression","volume":"297","author":"Chicoine","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2022031211383370200_B41","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","article-title":"Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions","volume":"52","author":"Roach","year":"2005","journal-title":"Arthritis Rheum"},{"key":"2022031211383370200_B42","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1152\/physiolgenomics.00157.2010","article-title":"MicroRNAs in skin and wound healing","volume":"43","author":"Banerjee","year":"2011","journal-title":"Physiol Genomics"},{"key":"2022031211383370200_B43","doi-asserted-by":"crossref","first-page":"29324","DOI":"10.1074\/jbc.M112.382135","article-title":"Induction of specific microRNAs inhibits cutaneous wound healing","volume":"287","author":"Pastar","year":"2012","journal-title":"J Biol Chem"},{"key":"2022031211383370200_B44","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/jcmm.12255","article-title":"Improved repair of dermal wounds in mice lacking microRNA-155","volume":"18","author":"van Solingen","year":"2014","journal-title":"J Cell Mol Med"},{"key":"2022031211383370200_B45","doi-asserted-by":"crossref","first-page":"16334","DOI":"10.1074\/jbc.M109.011601","article-title":"MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)","volume":"284","author":"Martinez-Nunez","year":"2009","journal-title":"J Biol Chem"},{"key":"2022031211383370200_B46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"2022031211383370200_B47","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"2022031211383370200_B48","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1038\/onc.2012.483","article-title":"miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer","volume":"32","author":"Su","year":"2013","journal-title":"Oncogene"},{"key":"2022031211383370200_B49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1684\/ejd.2017.3040","article-title":"MicroRNAs in skin wound healing","volume":"27","author":"Li","year":"2017","journal-title":"Eur J Dermatol"},{"key":"2022031211383370200_B50","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1172\/JCI79052","article-title":"MicroRNA-132 enhances transition from inflammation to proliferation during wound healing","volume":"125","author":"Li","year":"2015","journal-title":"J Clin Invest"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/diabetes.diabetesjournals.org\/syndication\/doi\/10.2337\/db17-1238","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/67\/8\/1627\/539091\/db171238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/67\/8\/1627\/539091\/db171238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:35:35Z","timestamp":1667406935000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/8\/1627\/16963\/MicroRNA-129-and-335-Promote-Diabetic-Wound"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,10]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,5,10]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db17-1238","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,10]]}}}