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Despite their widespread use, the sites of action through which GLP-1R agonists (GLP1RAs) affect appetite and body weight are still not fully understood. We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation. We found that mice lacking GLP-1Rs in vGAT-expressing GABAergic neurons responded identically to controls in all parameters measured, whereas deletion of GLP-1Rs in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced weight loss and visceral illness and severely attenuated its effects on feeding. Concomitantly, deletion of GLP-1Rs from glutamatergic neurons completely abolished the neural network activation observed after liraglutide administration. We conclude that liraglutide activates a dispersed but discrete neural network to mediate its physiological effects and that these effects require GLP-1R expression on glutamatergic but not GABAergic neurons.<\/jats:p>","DOI":"10.2337\/db17-1385","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T14:10:31Z","timestamp":1526652631000},"page":"1538-1548","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":154,"title":["Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor\u2013Expressing Glutamatergic Neurons"],"prefix":"10.2337","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-4213","authenticated-orcid":false,"given":"Jessica M.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Michigan, Ann Arbor, 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