{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:15Z","timestamp":1790774415299,"version":"4.1.0"},"reference-count":51,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p>Metabolic homeostasis is maintained by an interplay among tissues, organs, intracellular organelles, and molecules. Cidea and Cidec are lipid droplet (LD)\u2013associated proteins that promote lipid storage in brown adipose tissue (BAT) and white adipose tissue (WAT). Using ob\/ob\/Cidea\u2212\/\u2212, ob\/ob\/Cidec\u2212\/\u2212, and ob\/ob\/Cidea\u2212\/\u2212\/Cidec\u2212\/\u2212 mouse models and CIDE-deficient cells, we studied metabolic regulation during severe obesity to identify ways to maintain metabolic homeostasis and promote antiobesity effects. The phenotype of ob\/ob\/Cidea\u2212\/\u2212 mice was similar to that of ob\/ob mice in terms of serum parameters, adipose tissues, lipid storage, and gene expression. Typical lipodystrophy accompanied by insulin resistance occurred in ob\/ob\/Cidec\u2212\/\u2212 mice, with ectopic storage of lipids in the BAT and liver. Interestingly, double deficiency of Cidea and Cidec activated both WAT and BAT to consume more energy and to increase insulin sensitivity compared with their behavior in the other three mouse models. Increased lipolysis, which occurred on the LD surfaces and released fatty acids, led to activated \u03b2-oxidation and oxidative phosphorylation in peroxisomes and mitochondria in CIDE-deficient adipocytes. The coordination among LDs, peroxisomes, and mitochondria was regulated by adipocyte triglyceride lipase (ATGL)-peroxisome proliferator\u2013activated receptor \u03b1 (PPAR\u03b1). Double deficiency of Cidea and Cidec activated energy consumption in both WAT and BAT, which provided new insights into therapeutic approaches for obesity and diabetes.<\/jats:p>","DOI":"10.2337\/db17-1452","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T12:55:22Z","timestamp":1531140922000},"page":"1935-1948","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":58,"title":["Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPAR\u03b1 Pathway in Adipocytes"],"prefix":"10.2337","volume":"67","author":[{"given":"Linkang","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, People\u2019s Republic of 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