{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:29:59Z","timestamp":1774301399754,"version":"3.50.1"},"reference-count":28,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J000094\/1"],"award-info":[{"award-number":["MR\/J000094\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:p>Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 144) during oral glucose tolerance test (OGTT). GLP-1, glucose, and insulin were sampled at 30-min intervals during a 2-h 75-g OGTT, and indices of insulin secretion and sensitivity were calculated. In a nested case-control study, women with GDM (n = 19) had 12% lower total GLP-1 secretion area under the curve (AUC) compared with control subjects matched for age, ethnicity, and gestational age (n = 19), selected from within the lowest quartile of glucose120\u2008min values in our cohort. GDM had lower GLP-1 response in the first 30 min (19% lower GLP-130\u2008min and 17% lower AUC0\u201330\u2008min) after adjustment for possible confounders. Their glucose levels began to diverge at 30 min of the OGTT with increasing insulin levels, and by 120 min, their insulin levels were three times higher. In a secondary cohort of 57 women that included \u201chigh-normal\u201d glucose120\u2008min values, low GLP-1 AUC0\u201330\u2008min was independently associated with lower indices of insulin secretion and sensitivity. In conclusion, we have observed that women with GDM have lower GLP-1 response at 30 min of an OGTT and hyperglycemia at 120 min despite significant hyperinsulinemia.<\/jats:p>","DOI":"10.2337\/db18-0254","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T15:08:37Z","timestamp":1537369717000},"page":"2650-2656","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Reduced GLP-1 Secretion at 30 Minutes After a 75-g Oral Glucose Load Is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study"],"prefix":"10.2337","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-2061","authenticated-orcid":false,"given":"Nithya","family":"Sukumar","sequence":"first","affiliation":[{"name":"Populations, Evidence and Technologies Group, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, U.K."},{"name":"Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital NHS Trust, Nuneaton, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Bagias","sequence":"additional","affiliation":[{"name":"Populations, Evidence and Technologies Group, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, U.K."},{"name":"Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital NHS Trust, Nuneaton, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Goljan","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital NHS Trust, Nuneaton, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonas","family":"Weldeselassie","sequence":"additional","affiliation":[{"name":"Populations, Evidence and Technologies Group, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seley","family":"Gharanei","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and Leicester Diabetes Centre, University of Leicester, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bee K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and Leicester Diabetes Centre, University of Leicester, Leicester, U.K."},{"name":"Cell and Developmental Biology, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, U.K."},{"name":"Department of Obstetrics and Gynaecology, Birmingham University Hospitals of Leicester NHS Trust and University Hospital Birmingham NHS Foundation Trust, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens 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