{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:39:28Z","timestamp":1792093168173,"version":"4.4.0"},"reference-count":62,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"Wellcome Trust and Royal Society","award":["104150\/Z\/14\/Z"],"award-info":[{"award-number":["104150\/Z\/14\/Z"]}]},{"name":"European Research Council","award":["323195:GLUCOSEGENES-FP7-IDEAS-ERC"],"award-info":[{"award-number":["323195:GLUCOSEGENES-FP7-IDEAS-ERC"]}]},{"name":"Diabetes UK RD Lawrence fellowship","award":["17\/0005594"],"award-info":[{"award-number":["17\/0005594"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits. We report 14 alleles, including 7 newly characterized alleles, associated with higher adiposity but a favorable metabolic profile. Consistent with previous studies, individuals carrying more favorable adiposity alleles had higher body fat % and higher BMI but lower risk of type 2 diabetes, heart disease, and hypertension. These individuals also had higher subcutaneous fat but lower liver fat and a lower visceral-to-subcutaneous adipose tissue ratio. Individual alleles associated with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat but lower risk of type 2 diabetes. Most identified favorable adiposity alleles are associated with higher subcutaneous and lower liver fat, a mechanism consistent with the beneficial effects of storing excess triglycerides in metabolically low-risk depots.<\/jats:p>","DOI":"10.2337\/db18-0708","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T19:06:35Z","timestamp":1540321595000},"page":"207-219","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":96,"title":["Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension"],"prefix":"10.2337","volume":"68","author":[{"given":"Yingjie","family":"Ji","sequence":"first","affiliation":[{"name":"Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrianos M.","family":"Yiorkas","sequence":"additional","affiliation":[{"name":"Section of Investigative Medicine, Imperial College London, London, U.K."},{"name":"Department of Life Sciences, Brunel University London, Uxbridge, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Frau","sequence":"additional","affiliation":[{"name":"Translational Medicine and Early Development, TMED Translational Informatics, Sanofi, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Mook-Kanamori","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Staiger","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), T\u00fcbingen, Germany"},{"name":"Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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