{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:23:40Z","timestamp":1790511820889,"version":"4.1.0"},"reference-count":42,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>Available data from observational studies on the association of admission hyperglycemia (aHG) with outcomes of patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) are contradictory, especially when stratified by diabetes mellitus (DM) history. We assessed the association of aHG (\u2265144 mg\/dL) with outcomes stratified by DM history using propensity score\u2013matched (PSM) data from the SITS-ISTR. The primary safety outcome was symptomatic intracranial hemorrhage (SICH); 3-month functional independence (FI) (modified Rankin Scale [mRS] scores 0\u20132) represented the primary efficacy outcome. Patients with and without aHG did not differ in baseline characteristics both in the non-DM (n = 12,318) and DM (n = 6,572) PSM subgroups. In the non-DM group, patients with aHG had lower 3-month FI rates (53.3% vs. 57.9%, P &amp;lt; 0.001), higher 3-month mortality rates (19.2% vs. 16.0%, P &amp;lt; 0.001), and similar symptomatic intracerebral hemorrhage (SICH) rates (1.7% vs. 1.8%, P = 0.563) compared with patients without aHG. Similarly, in the DM group, patients with aHG had lower rates of 3-month favorable functional outcome (mRS scores 0\u20131, 34.1% vs. 39.3%, P &amp;lt; 0.001) and FI (48.2% vs. 52.5%, P &amp;lt; 0.001), higher 3-month mortality rates (23.7% vs. 19.9%, P &amp;lt; 0.001), and similar SICH rates (2.2% vs. 2.7%, P = 0.224) compared with patients without aHG. In conclusion, aHG was associated with unfavorable 3-month clinical outcomes in patients with and without DM and AIS treated with IVT.<\/jats:p>","DOI":"10.2337\/db19-0440","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T18:25:11Z","timestamp":1560968711000},"page":"1861-1869","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":67,"title":["Association of Baseline Hyperglycemia With Outcomes of Patients With and Without Diabetes With Acute Ischemic Stroke Treated With Intravenous Thrombolysis: A Propensity Score\u2013Matched Analysis From the SITS-ISTR Registry"],"prefix":"10.2337","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-3797","authenticated-orcid":false,"given":"Georgios","family":"Tsivgoulis","sequence":"first","affiliation":[{"name":"Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Department of Neurology, University of Tennessee Health Science Center, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis H.","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Department of Neurology, St. Josef-Hospital, Ruhr University, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Mavridis","sequence":"additional","affiliation":[{"name":"Department of Primary Education, University of Ioannina, Ioannina, Greece"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-4039","authenticated-orcid":false,"given":"Vaia","family":"Lambadiari","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Center, Second Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Roffe","sequence":"additional","affiliation":[{"name":"University Hospital of North Midlands, Stoke-on-Trent, U.K., and Keele University, Keele, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Joan","family":"Macleod","sequence":"additional","affiliation":[{"name":"Division of Applied Medicine, University of Aberdeen, Foresterhill, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Sevcik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Stroke Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Nev\u0161\u00edmalov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Ceske Budejovice, Statutory City, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Toni","sequence":"additional","affiliation":[{"name":"Neurovascular Unit, Policlinico Umberto I, Department of Human Neurosciences, University of Rome, \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"2022031303095921400_B1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/S0140-6736(09)60553-5","article-title":"Stress hyperglycaemia","volume":"373","author":"Dungan","year":"2009","journal-title":"Lancet"},{"key":"2022031303095921400_B2","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.2337\/dc06-0204","article-title":"Frequency and temporal profile of poststroke hyperglycemia using continuous glucose monitoring","volume":"29","author":"Allport","year":"2006","journal-title":"Diabetes Care"},{"key":"2022031303095921400_B3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/bmj.314.7090.1303","article-title":"Is hyperglycaemia an independent predictor of poor outcome after acute stroke? 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