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Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and related metabolic diseases remains elusive. In this study, we show that adipocyte-specific Becn1 knockout mice develop severe lipodystrophy, leading to adipose tissue inflammation, hepatic steatosis, and insulin resistance. Ablation of Becn1 in adipocytes stimulates programmed cell death in a cell-autonomous manner, accompanied by elevated endoplasmic reticulum (ER) stress gene expression. Furthermore, we observed that Becn1 depletion sensitized mature adipocytes to ER stress, leading to accelerated cell death. Taken together, these data suggest that adipocyte Becn1 would serve as a crucial player for adipocyte survival and adipose tissue homeostasis.<\/jats:p>","DOI":"10.2337\/db19-1239","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T05:20:11Z","timestamp":1602566411000},"page":"182-195","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":17,"title":["Depletion of Adipocyte <i>Becn1<\/i> Leads to Lipodystrophy and Metabolic Dysregulation"],"prefix":"10.2337","volume":"70","author":[{"given":"Young","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yul","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Center for Adipocyte Structure-Function, Institute of 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