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However, the causal relationship of these events remains unclear. The established dominance of STAT1 function in the immune response suggests an obligate link between inflammation and the comorbidities of obesity. To this end, we sought to determine how STAT1 activity in white adipocytes affects insulin sensitivity. STAT1 expression in WAT inversely correlated with fasting plasma glucose in both obese mice and humans. Metabolomic and gene expression profiling established STAT1 deletion in adipocytes (STAT1a-KO) enhanced mitochondrial function and accelerated tricarboxylic acid cycle flux coupled with reduced fat cell size in subcutaneous WAT depots. STAT1a-KO reduced WAT inflammation, but insulin resistance persisted in obese mice. Rather, elimination of type I cytokine interferon-\u03b3 activity enhanced insulin sensitivity in diet-induced obesity. Our findings reveal a permissive mechanism that bridges WAT inflammation to whole-body insulin sensitivity.<\/jats:p>","DOI":"10.2337\/db20-0384","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T21:05:14Z","timestamp":1601413514000},"page":"2630-2641","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":40,"title":["STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity"],"prefix":"10.2337","volume":"69","author":[{"given":"Aaron R.","family":"Cox","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Chernis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bader","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip K.","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Masschelin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Felix","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sharp","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqin","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanta","family":"Putluri","sequence":"additional","affiliation":[{"name":"Dan L. 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