{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:32:40Z","timestamp":1774049560834,"version":"3.50.1"},"reference-count":37,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009252","name":"Science for Life Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p>The longitudinal alterations of the pancreatic \u03b2-cell and islet mass in the progression of type 1 diabetes (T1D) are still poorly understood. The objective of this study was to repeatedly assess the endocrine volume and the morphology of the pancreas for up to 24 months after T1D diagnosis (n = 16), by 11C-5-hydroxytryptophan (11C-5-HTP) positron emission tomography (PET) and MRI. Study participants were examined four times by PET\/MRI: at recruitment and then after 6, 12, and 24 months. Clinical examinations and assessment of \u03b2-cell function by a mixed-meal tolerance test and fasting blood samples were performed in connection with the imaging examination. Pancreas volume has a tendency to decrease from 50.2 \u00b1 10.3 mL at T1D debut to 42.2 \u00b1 14.6 mL after 24 months (P &amp;lt; 0.098). Pancreas uptake of 11C-5-HTP (e.g., the volume of the endocrine pancreas) did not decrease from T1D diagnosis (0.23 \u00b1 0.10 % of injected dose) to 24-month follow-up, 0.21 \u00b1 0.14% of injected dose, and exhibited low interindividual changes. Pancreas perfusion was unchanged from diagnosis to 24-month follow-up. The pancreas uptake of 11C-5-HTP correlated with the long-term metabolic control as estimated by HbA1c (P &amp;lt; 0.05). Our findings argue against a major destruction of \u03b2-cell or islet mass in the 2-year period after diagnosis of T1D.<\/jats:p>","DOI":"10.2337\/db20-0776","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T20:50:41Z","timestamp":1611262241000},"page":"966-975","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":11,"title":["Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes"],"prefix":"10.2337","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-7941","authenticated-orcid":false,"given":"Daniel","family":"Espes","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-073X","authenticated-orcid":false,"given":"Per-Ola","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"},{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram Kumar","family":"Selvaraju","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rosestedt","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cheung","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"},{"name":"Antaros Medical AB, M\u00f6lndal, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-9547","authenticated-orcid":false,"given":"Olle","family":"Korsgren","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-8790","authenticated-orcid":false,"given":"Olof","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"2022031302165274000_B1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00125-013-3155-y","article-title":"Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study","volume":"57","author":"Krogvold","year":"2014","journal-title":"Diabetologia"},{"key":"2022031302165274000_B2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s00125-013-3159-7","article-title":"Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora\u2019s box","volume":"57","author":"Atkinson","year":"2014","journal-title":"Diabetologia"},{"key":"2022031302165274000_B3","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.2337\/db16-1449","article-title":"[11C]5-hydroxy-tryptophan PET for assessment of islet mass during progression of type 2 diabetes","volume":"66","author":"Carlbom","year":"2017","journal-title":"Diabetes"},{"key":"2022031302165274000_B4","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/ajt.14642","article-title":"Transplantation of macroencapsulated human islets within the bioartificial pancreas betaAir to patients with type 1 diabetes mellitus","volume":"18","author":"Carlsson","year":"2018","journal-title":"Am J Transplant"},{"key":"2022031302165274000_B5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01219468","article-title":"Monoamines in the pancreatic islets of the mouse. 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