{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:56:42Z","timestamp":1791943002424,"version":"4.3.4"},"reference-count":40,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>Methazolamide (MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit cardiomyocyte hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes and diabetic db\/db mice. However, whether MTZ has a cardioprotective effect in the setting of diabetic cardiomyopathy is not clear. We investigated the effects of MTZ in a mouse model of streptozotocin-induced type 1 diabetes mellitus (T1DM). Diabetic mice received MTZ by intragastric gavage (10, 25, or 50 mg\/kg, daily for 16 weeks). In the diabetic group, MTZ significantly reduced both random and fasting blood glucose levels and improved glucose tolerance in a dose-dependent manner. MTZ ameliorated T1DM-induced changes in cardiac morphology and dysfunction. Mechanistic analysis revealed that MTZ blunted T1DM-induced enhanced expression of \u03b2-catenin. Similar results were observed in neonatal rat cardiomyocytes (NRCMs) and adult mouse cardiomyocytes treated with high glucose or Wnt3a (a \u03b2-catenin activator). There was no significant change in \u03b2-catenin mRNA levels in cardiac tissues or NRCMs. MTZ-mediated \u03b2-catenin downregulation was recovered by MG132, a proteasome inhibitor. Immunoprecipitation and immunofluorescence analyses showed augmentation of AXIN1\u2013\u03b2-catenin interaction by MTZ in T1DM hearts and in NRCMs treated with Wnt3a; thus, MTZ may potentiate AXIN1\u2013\u03b2-catenin linkage to increase \u03b2-catenin degradation. Overall, MTZ may alleviate cardiac hypertrophy by mediating AXIN1\u2013\u03b2-catenin interaction to promote degradation and inhibition of \u03b2-catenin activity. These findings may help inform novel therapeutic strategy to prevent heart failure in patients with diabetes.<\/jats:p>","DOI":"10.2337\/db21-0506","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T23:28:08Z","timestamp":1642548488000},"page":"795-811","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":16,"title":["Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting \u03b2-Catenin Degradation in Type 1 Diabetic Mice"],"prefix":"10.2337","volume":"71","author":[{"given":"Xiaoqing","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conglin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Lian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"},{"name":"Zhujiang Hospital of Southern Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawen","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Dong","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-4946","authenticated-orcid":false,"given":"Ning","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"},{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"2022032220594636300_B1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ecl.2006.05.003","article-title":"Diabetic cardiomyopathy","volume":"35","author":"Fonarow","year":"2006","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2022032220594636300_B2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.amjmed.2008.03.046","article-title":"Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options","volume":"121","author":"Aneja","year":"2008","journal-title":"Am J Med"},{"key":"2022032220594636300_B3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1139\/y04-065","article-title":"Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes","volume":"82","author":"Severson","year":"2004","journal-title":"Can J Physiol Pharmacol"},{"key":"2022032220594636300_B4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cardfail.2014.02.007","article-title":"The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota","volume":"20","author":"Dandamudi","year":"2014","journal-title":"J Card Fail"},{"key":"2022032220594636300_B5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"2022032220594636300_B6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2261-13-2","article-title":"Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart","volume":"13","author":"Alvarez","year":"2013","journal-title":"BMC Cardiovasc Disord"},{"key":"2022032220594636300_B7","doi-asserted-by":"crossref","first-page":"e001974","DOI":"10.1161\/CIRCGENETICS.117.001974","article-title":"Proteomic analysis of the myocardium in hypertrophic obstructive cardiomyopathy","volume":"11","author":"Coats","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"2022032220594636300_B8","doi-asserted-by":"crossref","first-page":"e72111","DOI":"10.1371\/journal.pone.0072111","article-title":"Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance","volume":"8","author":"Gao","year":"2013","journal-title":"PLoS One"},{"key":"2022032220594636300_B9","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0895-7061(01)02161-6","article-title":"Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats","volume":"14","author":"Sharkey","year":"2001","journal-title":"Am J Hypertens"},{"key":"2022032220594636300_B10","doi-asserted-by":"crossref","first-page":"e000434","DOI":"10.1161\/JAHA.113.000434","article-title":"Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy","volume":"3","author":"Torella","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2022032220594636300_B11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.yjmcc.2011.12.008","article-title":"Carbonic anhydrase XIV in the normal and hypertrophic myocardium","volume":"52","author":"Vargas","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"2022032220594636300_B12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.carpath.2016.08.003","article-title":"Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats","volume":"25","author":"Vargas","year":"2016","journal-title":"Cardiovasc Pathol"},{"key":"2022032220594636300_B13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/01.HYP.0000173069.53699.d9","article-title":"Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure","volume":"46","author":"Domenighetti","year":"2005","journal-title":"Hypertension"},{"key":"2022032220594636300_B14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.yexmp.2018.10.003","article-title":"Cardioprotection of benzolamide in a regional ischemia model: Role of eNOS\/NO","volume":"105","author":"Gonz\u00e1lez Arbel\u00e1ez","year":"2018","journal-title":"Exp Mol Pathol"},{"key":"2022032220594636300_B15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1113\/jphysiol.2006.123638","article-title":"Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy","volume":"579","author":"Alvarez","year":"2007","journal-title":"J Physiol"},{"key":"2022032220594636300_B16","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2337\/db11-0578","article-title":"Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo","volume":"61","author":"Konstantopoulos","year":"2012","journal-title":"Diabetes"},{"key":"2022032220594636300_B17","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.2337\/dc14-1038","article-title":"Efficacy and safety of oral methazolamide in patients with type 2 diabetes: a 24-week, placebo-controlled, double-blind study","volume":"37","author":"Simpson","year":"2014","journal-title":"Diabetes Care"},{"key":"2022032220594636300_B18","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"2022032220594636300_B19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"2022032220594636300_B20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2009.09.101","article-title":"beta-Catenin\/TCF\/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes","volume":"390","author":"Zhang","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"2022032220594636300_B21","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1073\/pnas.0835895100","article-title":"Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth","volume":"100","author":"Haq","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022032220594636300_B22","doi-asserted-by":"crossref","first-page":"e003010","DOI":"10.1161\/CIRCHEARTFAILURE.116.003010","article-title":"Transcription factor 7-like 2 mediates canonical Wnt\/\u03b2-catenin signaling and c-Myc upregulation in heart failure","volume":"9","author":"Hou","year":"2016","journal-title":"Circ Heart Fail"},{"key":"2022032220594636300_B23","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.bbrc.2017.10.027","article-title":"Activation of nuclear \u03b2-catenin\/c-Myc axis promotes oxidative stress injury in streptozotocin-induced diabetic cardiomyopathy","volume":"493","author":"Liu","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"2022032220594636300_B24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.carpath.2014.12.002","article-title":"Activation of Wnt\/\u03b2-catenin\/GSK3\u03b2 signaling during the development of diabetic cardiomyopathy","volume":"24","author":"Xi","year":"2015","journal-title":"Cardiovasc Pathol"},{"key":"2022032220594636300_B25","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.freeradbiomed.2020.09.012","article-title":"BRG1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the NRF2\/HO1 signaling pathway","volume":"160","author":"Liu","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2022032220594636300_B26","doi-asserted-by":"crossref","first-page":"E7116","DOI":"10.1073\/pnas.1607728113","article-title":"PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction","volume":"113","author":"Knight","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022032220594636300_B27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2443.1998.00198.x","article-title":"Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level","volume":"3","author":"Nakamura","year":"1998","journal-title":"Genes Cells"},{"key":"2022032220594636300_B28","doi-asserted-by":"crossref","first-page":"17706","DOI":"10.1074\/jbc.M111982200","article-title":"Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways","volume":"277","author":"Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"2022032220594636300_B29","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"2022032220594636300_B30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/cr.2011.127","article-title":"Small molecule-based disruption of the Axin\/\u03b2-catenin protein complex regulates mesenchymal stem cell differentiation","volume":"22","author":"Gwak","year":"2012","journal-title":"Cell Res"},{"key":"2022032220594636300_B31","doi-asserted-by":"crossref","first-page":"108440","DOI":"10.1016\/j.abb.2020.108440","article-title":"Role of carbonic anhydrases in ferroptosis-resistance","volume":"689","author":"Li","year":"2020","journal-title":"Arch Biochem Biophys"},{"key":"2022032220594636300_B32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1573399812666161214122351","article-title":"The role of carbonic anhydrase in hepatic glucose production","volume":"14","author":"Ismail","year":"2018","journal-title":"Curr Diabetes Rev"},{"key":"2022032220594636300_B33","first-page":"E791","article-title":"Mitochondrial carbonic anhydrase is involved in rat renal glucose synthesis","volume":"257","author":"Dodgson","year":"1989","journal-title":"Am J Physiol"},{"key":"2022032220594636300_B34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0003-9861(86)90066-4","article-title":"Inhibition of CA V decreases glucose synthesis from pyruvate","volume":"251","author":"Dodgson","year":"1986","journal-title":"Arch Biochem Biophys"},{"key":"2022032220594636300_B35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1517\/14728214.2012.664132","article-title":"Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity","volume":"17","author":"Supuran","year":"2012","journal-title":"Expert Opin Emerg Drugs"},{"key":"2022032220594636300_B36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11596-020-2144-x","article-title":"Inhibition of NF-\u03baB and Wnt\/\u03b2-catenin\/GSK3\u03b2 signaling pathways ameliorates cardiomyocyte hypertrophy and fibrosis in streptozotocin (STZ)-induced type 1 diabetic rats","volume":"40","author":"Liu","year":"2020","journal-title":"Curr Med Sci"},{"key":"2022032220594636300_B37","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1038\/s41467-019-12143-3","article-title":"USP7 inhibits Wnt\/\u03b2-catenin signaling through promoting stabilization of Axin","volume":"10","author":"Ji","year":"2019","journal-title":"Nat Commun"},{"key":"2022032220594636300_B38","doi-asserted-by":"crossref","first-page":"36085","DOI":"10.1074\/jbc.M111952200","article-title":"Carbonic anhydrase II binds to and enhances activity of the Na+\/H+ exchanger","volume":"277","author":"Li","year":"2002","journal-title":"J Biol Chem"},{"key":"2022032220594636300_B39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1139\/y06-065","article-title":"Physiological role and regulation of the Na+\/H+ exchanger","volume":"84","author":"Malo","year":"2006","journal-title":"Can J Physiol Pharmacol"},{"key":"2022032220594636300_B40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1517\/14728220802600707","article-title":"Regulation of the Na(+)\/H(+) exchanger in the healthy and diseased myocardium","volume":"13","author":"Fliegel","year":"2009","journal-title":"Expert Opin Ther Targets"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/71\/4\/795\/671848\/db210506.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/71\/4\/795\/671848\/db210506.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T12:43:43Z","timestamp":1667393023000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/4\/795\/139251\/Methazolamide-Attenuates-the-Development-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,1,18]]},"published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-0506","relation":{"has-preprint":[{"id-type":"doi","id":"10.2337\/figshare.17430266.v1","asserted-by":"object"},{"id-type":"doi","id":"10.2337\/figshare.17430266","asserted-by":"object"}]},"ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,18]]}}}