{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:32:05Z","timestamp":1784917925509,"version":"3.55.0"},"reference-count":59,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>Childhood obesity is a growing worldwide problem. In adults, lower cold-induced brown adipose tissue (BAT) activity is linked to obesity and metabolic dysfunction; this relationship remains uncertain in children. In this cross-sectional study, we compared cold-induced supraclavicular (SCV) BAT activity (percent change in proton density fat fraction [PDFF]) within the SCV region after 1 h of whole-body cold exposure (18\u00b0C), using MRI in 26 boys aged 8\u201310 years: 13 with normal BMI and 13 with overweight\/obesity. Anthropometry, body composition, hepatic fat, visceral adipose tissue (VAT), and pre- and postcold PDFF of the subcutaneous adipose tissue (SAT) in the posterior neck region and the abdomen were measured. Boys with overweight\/obesity had lower cold-induced percent decline in SCV PDFF compared with those with normal BMI (1.6 \u00b1 0.8 vs. 4.7 \u00b1 1.2%, P = 0.044). SCV PDFF declined significantly in boys with normal BMI (2.7 \u00b1 0.7%, P = 0.003) but not in boys with overweight\/obesity (1.1 \u00b1 0.5%, P = 0.053). No cold-induced changes in the PDFF of either neck SAT (\u22120.89 \u00b1 0.7%, P = 0.250, vs. 0.37 \u00b1 0.3%, P = 0.230) or abdominal SAT (\u22120.39 \u00b1 0.5%, P = 0.409, and 0.25 \u00b1 0.2%, P = 0.139, for normal BMI and overweight\/obesity groups, respectively) were seen. The cold-induced percent decline in SCV PDFF was inversely related to BMI (r = \u22120.39, P = 0.047), waist circumference (r = \u22120.48, P = 0.014), and VAT (r = \u22120.47, P = 0.014). Thus, in young boys, as in adults, BAT activity is lower in those with overweight\/obesity, suggesting that restoring activity may be important for improving metabolic health.<\/jats:p>","DOI":"10.2337\/db21-0799","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T10:58:33Z","timestamp":1647428313000},"page":"1193-1204","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys With Obesity"],"prefix":"10.2337","volume":"71","author":[{"given":"Basma A.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, 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