{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:24:20Z","timestamp":1779377060471,"version":"3.53.1"},"reference-count":24,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":137,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p>Reports indicate that coronavirus disease 2019 (COVID-19) may impact pancreatic function and increase type 2 diabetes (T2D) risk, although real-world COVID-19 impacts on HbA1c and T2D are unknown. We tested whether COVID-19 increased HbA1c, risk of T2D, or diabetic ketoacidosis (DKA). We compared pre\u2013 and post\u2013COVID-19 HbA1c and T2D risk in a large real-world clinical cohort of 8,755 COVID-19(+) patients and 11,998 COVID-19(\u2212) matched control subjects. We investigated whether DKA risk was modified in COVID-19(+) patients with type 1 diabetes (T1D) (N = 701) or T2D (N = 21,830), or by race and sex. We observed a statistically significant, albeit clinically insignificant, HbA1c increase post\u2013COVID-19 (all patients \u0394HbA1c = 0.06%; with T2D \u0394HbA1c = 0.1%) and no increase among COVID-19(\u2212) patients. COVID-19(+) patients were 40% more likely to be diagnosed with T2D compared with COVID-19(\u2212) patients and 28% more likely for the same HbA1c change as COVID-19(\u2212) patients, indicating that COVID-19\u2013attributed T2D risk may be due to increased recognition during COVID-19 management. DKA in COVID-19(+) patients with T1D was not increased. COVID-19(+) Black patients with T2D displayed disproportionately increased DKA risk (hazard ratio 2.46 [95% CI 1.48\u20136.09], P = 0.004) compared with White patients, suggesting a need for further clinical awareness and investigation.<\/jats:p>","DOI":"10.2337\/db22-0264","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T11:49:31Z","timestamp":1663242571000},"page":"627-637","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["Impacts of COVID-19 on Glycemia and Risk of Diabetic Ketoacidosis"],"prefix":"10.2337","volume":"72","author":[{"given":"Anukriti","family":"Sharma","sequence":"first","affiliation":[{"name":"1Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita D.","family":"Misra-Hebert","sequence":"additional","affiliation":[{"name":"1Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH"},{"name":"2Department of Internal Medicine, Cleveland Clinic Community Care, Cleveland Clinic, Cleveland, OH"},{"name":"3Healthcare Delivery and Implementation Science Center, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshiya","family":"Mariam","sequence":"additional","affiliation":[{"name":"1Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Milinovich","sequence":"additional","affiliation":[{"name":"1Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Onuzuruike","sequence":"additional","affiliation":[{"name":"4Cleveland Clinic Lerner College of Medicine, Case Western Reserve 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