{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:55:04Z","timestamp":1790067304388,"version":"4.0.1"},"reference-count":12,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0925"],"award-info":[{"award-number":["01GI0925"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p>The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. We assigned 1,045 participants from the Prediabetes Lifestyle Intervention Study (PLIS) to six recently established prediabetes clusters. Insulin secretion was assessed by a C-peptide\u2013based index derived from oral glucose tolerance tests and modeled from three time points during a 1-year intervention. We also analyzed the change of glycemia, insulin sensitivity, and liver fat. All prediabetes high-risk clusters (cluster 3, 5, and 6) had improved glycemic traits during the lifestyle intervention, whereas insulin secretion only increased in clusters 3 and 5 (P &amp;lt; 0.001); however, high liver fat in cluster 5 was associated with a failure to improve insulin secretion (Pinteraction &amp;lt; 0.001). Thus, interventions to reduce liver fat have the potential to improve insulin secretion in a defined subgroup of prediabetes.<\/jats:p>","DOI":"10.2337\/db22-0441","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T14:06:23Z","timestamp":1671199583000},"page":"362-366","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":24,"title":["Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention"],"prefix":"10.2337","volume":"72","author":[{"given":"Robert","family":"Wagner","sequence":"first","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"2Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"4Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"5Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Heni","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"2Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"6Division of Endocrinology and Diabetology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany"},{"name":"7Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kantartzis","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"2Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Sandforth","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"2Division of Diabetology, Endocrinology and Nephrology, Department of Internal Medicine IV, Eberhard-Karls University T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Machann","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"8Section on Experimental Radiology, Department of Radiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Schick","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"8Section on Experimental Radiology, Department of Radiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"7Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fritsche","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"3Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Szendr\u00f6di","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"9Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany"},{"name":"10Institute for Diabetes and Cancer, IDC Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes Program, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas F.H.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"11Department of Endocrinology & Metabolism, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"12Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"13Department of Medicine, Endocrinology and Nephrology, Universit\u00e4t Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hauner","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"14Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Seissler","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"15Diabetes Center, Medical Department 4, LMU University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bornstein","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"16Department of Internal Medicine III, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-6382","authenticated-orcid":false,"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"1German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"4Department of Endocrinology and Diabetology, Medical 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