{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:24:05Z","timestamp":1788452645457,"version":"build-2803163510"},"reference-count":71,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["MOH-CSAINV21jun-0001"],"award-info":[{"award-number":["MOH-CSAINV21jun-0001"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["NMRC\/OFLCG\/001\/2017"],"award-info":[{"award-number":["NMRC\/OFLCG\/001\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>Diabetic corneal neuropathy (DCN) is a common complication of diabetes. However, there are very limited therapeutic options. We investigated the effects of a peroxisome proliferator\u2013activated receptor-\u03b1 (PPAR-\u03b1) agonist, fenofibrate, on 30 patients (60 eyes) with type 2 diabetes. On in\u00a0vivo confocal microscopy evaluation, there was significant stimulation of corneal nerve regeneration and a reduction in nerve edema after 30 days of oral fenofibrate treatment, as evidenced by significant improvement in corneal nerve fiber density (CNFD) and corneal nerve fiber width, respectively. Corneal epithelial cell morphology also significantly improved in cell circularity. Upon clinical examination, fenofibrate significantly improved patients\u2019 neuropathic ocular surface status by increasing tear breakup time along with a reduction of corneal and conjunctival punctate keratopathy. Tear substance P (SP) concentrations significantly increased after treatment, suggesting an amelioration of ocular surface neuroinflammation. The changes in tear SP concentrations was also significantly associated with improvement in CNFD. Quantitative proteomic analysis demonstrated that fenofibrate significantly upregulated and modulated the neurotrophin signaling pathway and linolenic acid, cholesterol, and fat metabolism. Complement cascades, neutrophil reactions, and platelet activation were also significantly suppressed. Our results showed that fenofibrate could potentially be a novel treatment for patients with DCN.<\/jats:p>","DOI":"10.2337\/db22-0611","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T14:06:44Z","timestamp":1669730804000},"page":"932-946","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":43,"title":["Oral Peroxisome Proliferator\u2013Activated Receptor-\u03b1 Agonist Enhances Corneal Nerve Regeneration in Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-3664","authenticated-orcid":false,"given":"Calesta Hui Yi","family":"Teo","sequence":"first","affiliation":[{"name":"1Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly Tzu-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"2Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Xin Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"2Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew-Kwan","family":"Koh","sequence":"additional","affiliation":[{"name":"3Ocular Proteomic Group, Singapore Eye Research Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"3Ocular Proteomic Group, Singapore Eye Research Institute, Singapore"},{"name":"4Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore"},{"name":"5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan Shaoying","family":"Goh","sequence":"additional","affiliation":[{"name":"6Department of Pharmacy, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwon","family":"Choi","sequence":"additional","affiliation":[{"name":"7Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi Wai Ling","family":"Koh","sequence":"additional","affiliation":[{"name":"7Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Yun Rui","family":"Lam","sequence":"additional","affiliation":[{"name":"8Department of Endocrinology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paik Shia","family":"Lim","sequence":"additional","affiliation":[{"name":"9Department of Pharmacy, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodhbir S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"2Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore"},{"name":"4Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore"},{"name":"10Cornea and Refractive Surgery Group, Singapore Eye Research Institute, Singapore"},{"name":"11Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Kovalik","sequence":"additional","affiliation":[{"name":"12Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Coffman","sequence":"additional","affiliation":[{"name":"12Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Chang","family":"Tan","sequence":"additional","affiliation":[{"name":"8Department of Endocrinology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-0382","authenticated-orcid":false,"given":"Yu-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"2Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore"},{"name":"4Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore"},{"name":"10Cornea and Refractive Surgery Group, Singapore Eye Research Institute, Singapore"},{"name":"11Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"2023080212565455100_B1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.clinthera.2018.04.001","article-title":"Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy","volume":"40","author":"Iqbal","year":"2018","journal-title":"Clin Ther"},{"key":"2023080212565455100_B2","doi-asserted-by":"crossref","first-page":"816062","DOI":"10.3389\/fphar.2022.816062","article-title":"Diabetic corneal neuropathy: pathogenic mechanisms and therapeutic strategies","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"key":"2023080212565455100_B3","article-title":"Peripheral Diabetic Neuropathy","author":"Bodman","year":"2022"},{"key":"2023080212565455100_B4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/aos.13844","article-title":"Role of corneal nerves in ocular surface homeostasis and disease","volume":"97","author":"Labetoulle","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"2023080212565455100_B5","doi-asserted-by":"crossref","first-page":"100762","DOI":"10.1016\/j.preteyeres.2019.05.003","article-title":"Corneal nerves in health and disease","volume":"73","author":"Al-Aqaba","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"2023080212565455100_B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9123956","article-title":"Diabetic corneal neuropathy","volume":"9","author":"Mansoor","year":"2020","journal-title":"J Clin Med"},{"key":"2023080212565455100_B7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajo.2020.04.036","article-title":"In vivo evaluation of corneal nerves and epithelial healing after treatment with recombinant nerve growth factor for neurotrophic keratopathy","volume":"217","author":"Mastropasqua","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"2023080212565455100_B8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2217\/fca-2017-0019","article-title":"PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-\u03b2\/\u03b4 and PPAR-\u03b3","volume":"13","author":"Han","year":"2017","journal-title":"Future Cardiol"},{"key":"2023080212565455100_B9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.semcdb.2012.01.003","article-title":"PPARs: fatty acid sensors controlling metabolism","volume":"23","author":"Poulsen","year":"2012","journal-title":"Semin Cell Dev Biol"},{"key":"2023080212565455100_B10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2165\/00003495-199040020-00007","article-title":"Fenofibrate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia","volume":"40","author":"Balfour","year":"1990","journal-title":"Drugs"},{"key":"2023080212565455100_B11","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2337\/db08-1771","article-title":"Elevated triglycerides correlate with progression of diabetic neuropathy","volume":"58","author":"Wiggin","year":"2009","journal-title":"Diabetes"},{"key":"2023080212565455100_B12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbi.2021.01.004","article-title":"Targeting peroxisome proliferator-activated receptor-\u03b1 (PPAR-\u03b1) to reduce paclitaxel-induced peripheral neuropathy","volume":"93","author":"Caillaud","year":"2021","journal-title":"Brain Behav Immun"},{"key":"2023080212565455100_B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.68457","article-title":"Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair","volume":"10","author":"Avraham","year":"2021","journal-title":"eLife"},{"key":"2023080212565455100_B14","doi-asserted-by":"crossref","first-page":"e83204","DOI":"10.1371\/journal.pone.0083204","article-title":"Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db\/db mice","volume":"9","author":"Cho","year":"2014","journal-title":"PLoS One"},{"key":"2023080212565455100_B15","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(05)67667-2","article-title":"Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial","volume":"366","author":"Keech","year":"2005","journal-title":"Lancet"},{"key":"2023080212565455100_B16","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2337\/db19-0898","article-title":"Pathogenic role of PPAR\u03b1 downregulation in corneal nerve degeneration and impaired corneal sensitivity in diabetes","volume":"69","author":"Matlock","year":"2020","journal-title":"Diabetes"},{"key":"2023080212565455100_B17","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3928\/1081597X-20200730-01","article-title":"Cross-sectional study on corneal denervation in contralateral eyes following SMILE versus LASIK","volume":"36","author":"Liu","year":"2020","journal-title":"J Refract Surg"},{"key":"2023080212565455100_B18","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4103\/1673-5374.289435","article-title":"Analysis of corneal nerve plexus in corneal confocal microscopy images","volume":"16","author":"Liu","year":"2021","journal-title":"Neural Regen Res"},{"key":"2023080212565455100_B19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1167\/iovs.17-23342","article-title":"Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy","volume":"59","author":"Chen","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023080212565455100_B20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/ICO.0b013e31825ab9e2","article-title":"Rapid image evaluation system for corneal in\u00a0vivo confocal microscopy","volume":"32","author":"Sindt","year":"2013","journal-title":"Cornea"},{"key":"2023080212565455100_B21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/mi.2015.47","article-title":"Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection","volume":"9","author":"Yawata","year":"2016","journal-title":"Mucosal Immunol"},{"key":"2023080212565455100_B22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jtos.2020.06.008","article-title":"Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients","volume":"18","author":"Teo","year":"2020","journal-title":"Ocul Surf"},{"key":"2023080212565455100_B23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00003226-200310000-00008","article-title":"Grading of corneal and conjunctival staining in the context of other dry eye tests","volume":"22","author":"Bron","year":"2003","journal-title":"Cornea"},{"key":"2023080212565455100_B24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3928\/1081597X-20210423-01","article-title":"Tear neuromediator and corneal denervation following SMILE","volume":"37","author":"Chin","year":"2021","journal-title":"J Refract Surg"},{"key":"2023080212565455100_B25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jare.2020.11.001","article-title":"Comparison of tear proteomic and neuromediator profiles changes between small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (LASIK)","volume":"29","author":"Liu","year":"2020","journal-title":"J Adv Res"},{"key":"2023080212565455100_B26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jprot.2015.09.013","article-title":"mapDIA: preprocessing and statistical analysis of quantitative proteomics data from data independent acquisition mass spectrometry","volume":"129","author":"Teo","year":"2015","journal-title":"J Proteomics"},{"key":"2023080212565455100_B27","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023080212565455100_B28","first-page":"75","article-title":"The role of Smad proteins for development, differentiation and dedifferentiation of neurons","author":"Ueberham","year":"2013","journal-title":"Trends in Cell Signaling Pathways in Neuronal Fate Decision"},{"key":"2023080212565455100_B29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3389\/fphys.2019.00644","article-title":"Cytochrome c oxidase on the crossroads of transcriptional regulation and bioenergetics","volume":"10","author":"Chicherin","year":"2019","journal-title":"Front Physiol"},{"key":"2023080212565455100_B30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.61.12.26","article-title":"The relationship between corneal nerve density and hemoglobin A1c in patients with prediabetes and type 2 diabetes","volume":"61","author":"Chao","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023080212565455100_B31","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1111\/jcmm.15112","article-title":"DNase I improves corneal epithelial and nerve regeneration in diabetic mice","volume":"24","author":"Zhang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2023080212565455100_B32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/01.ico.0000224640.58848.54","article-title":"Morphologic alterations of both the stromal and subbasal nerves in the corneas of patients with diabetes","volume":"25","author":"Mocan","year":"2006","journal-title":"Cornea"},{"key":"2023080212565455100_B33","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.4103\/1673-5374.327364","article-title":"Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy","volume":"17","author":"So","year":"2022","journal-title":"Neural Regen Res"},{"key":"2023080212565455100_B34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0014-4886(80)90154-5","article-title":"Sensory denervation of the rabbit cornea affects epithelial properties","volume":"69","author":"Beuerman","year":"1980","journal-title":"Exp Neurol"},{"key":"2023080212565455100_B35","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41401-019-0223-y","article-title":"Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling","volume":"40","author":"Jiang","year":"2019","journal-title":"Acta Pharmacol Sin"},{"key":"2023080212565455100_B36","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1167\/iovs.16-21372","article-title":"Corneal epithelium-derived neurotrophic factors promote nerve regeneration","volume":"58","author":"Di","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023080212565455100_B37","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/dc07-0175","article-title":"Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes","volume":"30","author":"Tavakoli","year":"2007","journal-title":"Diabetes Care"},{"key":"2023080212565455100_B38","first-page":"358","article-title":"Ocular surface changes in type II diabetic patients with proliferative diabetic retinopathy","volume":"8","author":"Gao","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"2023080212565455100_B39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"2023080212565455100_B40","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/ICO.0b013e3180950083","article-title":"A simple approach to the repeatability of the Schirmer test without anesthesia: eyes open or closed?","volume":"26","author":"Serin","year":"2007","journal-title":"Cornea"},{"key":"2023080212565455100_B41","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.2337\/db14-0163","article-title":"Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor","volume":"63","author":"Yang","year":"2014","journal-title":"Diabetes"},{"key":"2023080212565455100_B42","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jtos.2019.08.010","article-title":"Tear film substance P: a potential biomarker for diabetic peripheral neuropathy","volume":"17","author":"Tummanapalli","year":"2019","journal-title":"Ocul Surf"},{"key":"2023080212565455100_B43","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/OPX.0000000000001096","article-title":"Corneal nerve morphology and tear film substance p in diabetes","volume":"94","author":"Markoulli","year":"2017","journal-title":"Optom Vis Sci"},{"key":"2023080212565455100_B44","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1464-5491.2009.02856.x","article-title":"Nerve growth factor and expression of its receptors in patients with diabetic neuropathy","volume":"26","author":"Kim","year":"2009","journal-title":"Diabet Med"},{"key":"2023080212565455100_B45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(97)00350-9","article-title":"trkA and trkC expression is increased in human diabetic skin","volume":"228","author":"Terenghi","year":"1997","journal-title":"Neurosci Lett"},{"key":"2023080212565455100_B46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3940(95)12067-E","article-title":"Expression of neurotrophins and their receptors in sciatic nerve of experimentally diabetic rats","volume":"200","author":"Rodr\u00edguez-Pe\u00f1a","year":"1995","journal-title":"Neurosci Lett"},{"key":"2023080212565455100_B47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12986-020-00523-2","article-title":"Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion in the second trimester: a case-control study in Chinese","volume":"17","author":"Tang","year":"2020","journal-title":"Nutr Metab (Lond)"},{"key":"2023080212565455100_B48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp Eye Res"},{"key":"2023080212565455100_B49","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4103\/1673-5374.308666","article-title":"Corneal neuromediator profiles following laser refractive surgery","volume":"16","author":"Yang","year":"2021","journal-title":"Neural Regen Res"},{"key":"2023080212565455100_B50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2202-7-45","article-title":"Activation of MAPK ERK in peripheral nerve after injury","volume":"7","author":"Agthong","year":"2006","journal-title":"BMC Neurosci"},{"key":"2023080212565455100_B51","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/B978-0-323-29738-7.00033-2","article-title":"Chapter 33 - complications of diabetes mellitus","author":"Brownlee","year":"2016","journal-title":"Williams Textbook of Endocrinology"},{"key":"2023080212565455100_B52","doi-asserted-by":"crossref","first-page":"e87255","DOI":"10.1371\/journal.pone.0087255","article-title":"Increased axonal ribosome numbers is an early event in the pathogenesis of amyotrophic lateral sclerosis","volume":"9","author":"Verheijen","year":"2014","journal-title":"PLoS One"},{"key":"2023080212565455100_B53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.expneurol.2009.08.033","article-title":"Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy","volume":"223","author":"Tavakoli","year":"2010","journal-title":"Exp Neurol"},{"key":"2023080212565455100_B54","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MOL.0000000000000770","article-title":"Lipids and peripheral neuropathy","volume":"32","author":"Iqbal","year":"2021","journal-title":"Curr Opin Lipidol"},{"key":"2023080212565455100_B55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21145093","article-title":"Combination of peroxisome proliferator-activated receptor (Ppar) alpha and gamma agonists prevents corneal inflammation and neovascularization in a rat alkali burn model","volume":"21","author":"Nakano","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023080212565455100_B56","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023080212565455100_B57","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1523\/JNEUROSCI.5646-03.2004","article-title":"A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel","volume":"24","author":"Levenson","year":"2004","journal-title":"J Neurosci"},{"key":"2023080212565455100_B58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tins.2011.03.001","article-title":"Regulation of neural process growth, elaboration and structural plasticity by NF-\u03baB","volume":"34","author":"Gutierrez","year":"2011","journal-title":"Trends Neurosci"},{"key":"2023080212565455100_B59","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood-2006-04-014779","article-title":"Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I","volume":"108","author":"Nasirikenari","year":"2006","journal-title":"Blood"},{"key":"2023080212565455100_B60","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/jdi.13535","article-title":"Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus","volume":"12","author":"Qian","year":"2021","journal-title":"J Diabetes Investig"},{"key":"2023080212565455100_B61","doi-asserted-by":"crossref","first-page":"41723","DOI":"10.1038\/srep41723","article-title":"Serum protein changes in a rat model of chronic pain show a correlation between animal and humans","volume":"7","author":"Bellei","year":"2017","journal-title":"Sci Rep"},{"key":"2023080212565455100_B62","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1167\/iovs.14-14307","article-title":"Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea","volume":"55","author":"Leppin","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023080212565455100_B63","doi-asserted-by":"crossref","first-page":"e0115320","DOI":"10.1371\/journal.pone.0115320","article-title":"Serum amyloid a truncations in type 2 diabetes mellitus","volume":"10","author":"Yassine","year":"2015","journal-title":"PLoS One"},{"key":"2023080212565455100_B64","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00125-010-1996-1","article-title":"Genetic associations in diabetic nephropathy: a meta-analysis","volume":"54","author":"Mooyaart","year":"2011","journal-title":"Diabetologia"},{"key":"2023080212565455100_B65","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/jdi.13739","article-title":"Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: evidence from transcriptomic data and renal histopathology","volume":"13","author":"Jiao","year":"2022","journal-title":"J Diabetes Investig"},{"key":"2023080212565455100_B66","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresbull.2020.02.004","article-title":"TTC9A deficiency induces estradiol-mediated changes in hippocampus and amygdala neuroplasticity-related gene expressions in female mice","volume":"157","author":"Guan","year":"2020","journal-title":"Brain Res Bull"},{"key":"2023080212565455100_B67","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/membranes4040642","article-title":"The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors","volume":"4","author":"Bucci","year":"2014","journal-title":"Membranes (Basel)"},{"key":"2023080212565455100_B68","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.semcdb.2013.12.012","article-title":"B-type lamins in health and disease","volume":"29","author":"Hutchison","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"2023080212565455100_B69","doi-asserted-by":"crossref","first-page":"E493","DOI":"10.3390\/diagnostics10070493","article-title":"Validation of the use of automated and manual quantitative analysis of corneal nerve plexus following refractive surgery","volume":"10","author":"Chin","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"2023080212565455100_B70","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jacl.2015.03.011","article-title":"Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: a novel approach for treating diabetic neuropathy?","volume":"9","author":"Othman","year":"2015","journal-title":"J Clin Lipidol"},{"key":"2023080212565455100_B71","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00592-014-0610-2","article-title":"Effect of fenofibrate on retinal neurodegeneration in an experimental model of type 2 diabetes","volume":"52","author":"Bogdanov","year":"2015","journal-title":"Acta Diabetol"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/72\/7\/932\/729923\/db220611.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/72\/7\/932\/729923\/db220611.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T08:57:31Z","timestamp":1690966651000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/7\/932\/147959\/Oral-Peroxisome-Proliferator-Activated-Receptor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,11,29]]},"published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-0611","relation":{"has-preprint":[{"id-type":"doi","id":"10.2337\/figshare.21583392","asserted-by":"object"},{"id-type":"doi","id":"10.2337\/figshare.21583392.v1","asserted-by":"object"}]},"ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,29]]}}}